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Bacterial strain with anti-aging function and application thereof

An anti-aging, strain technology applied in the field of microbiology to achieve the effect of enhancing muscle strength

Active Publication Date: 2021-09-28
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few studies have pointed out the relationship between aging and microbiota. Our study found that Lactobacillus (34-10B), a microbial bacterium isolated from the intestinal tract of mice, plays a significant role in anti-aging, which provides a basis for microbial regulation of aging. research Foundation

Method used

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  • Bacterial strain with anti-aging function and application thereof
  • Bacterial strain with anti-aging function and application thereof
  • Bacterial strain with anti-aging function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Adding Bacillus velezensis SG.X-1 to Drinking Water Effects on Mouse Survival Rate

[0037] In the experiment, 6-week-old C57BL6 / J mice were used as the model and divided into two groups. The drinking water of the control group was supplemented with normal saline, and the drinking water of the experimental group was supplemented with Bacillus velezensis SG.X-1 (concentration of 5×105 CFU / mL), the number of surviving mice was determined every month. The results are attached Figure 4 shown by the attached Figure 4 It can be shown that adding Bacillus velezensis SG.X-1 to drinking water significantly increases the survival rate of mice.

Embodiment 2

[0038] Example 2 Effects of Adding Bacillus velezensis SG.X-1 to the Drinking Water on the Growth Performance of Old Rats

[0039] In the experiment, 24-month-old C57BL6 / J mice were used as models, and were divided into two groups. The drinking water of the control group was supplemented with normal saline, and the drinking water of the experimental group was supplemented with Bacillus velezensis SG.X-1 (concentration of 5×10 5 CFU / mL). After 11 weeks, the growth performance index of the mice was measured, and the results showed that the body weight of the mice increased significantly after the drinking water was added with Bacillus velezensis SG.X-1, as Figure 5 A; Feed intake has no effect, such as Figure 5 b. At the same time, it was found that the increase in body weight of the mice was mainly due to the increase in muscle, such as Figure 5 C; no significant effect on fat, such as Figure 5 d. This suggests that supplementation of drinking water with Bacillus vele...

Embodiment 3

[0040] Example 3 Effect of Adding Bacillus velezensis SG.X-1 to Drinking Water on Muscle Strength of Old Rats

[0041] In the experiment, 24-month-old C57BL6 / J mice were used as models, and were divided into two groups. The drinking water of the control group was supplemented with normal saline, and the drinking water of the treatment group was supplemented with Bacillus velezensis SG.X-1 (concentration of 5×10 5 CFU / mL). After 11 weeks, the muscular strength index of the mice was measured, and the results showed that drinking water added Bacillus velezensis SG.X-1 significantly increased the hanging time of the mice (such as Figure 6 A), claw grip (such as Figure 6 B), fast running time (such as Figure 6 C) and jogging time (eg Figure 6 D), showing that Bacillus velezensis SG.X-1 increases muscle strength.

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Abstract

The invention discloses a bacterial strain with an anti-aging function. The bacterial strain is a bacillus velezensis SG.X-1 bacterial strain; the bacterial strain is preserved in Guangdong Microbial Culture Collection Center, the preservation number is GDMCC NO.61197, and the preservation date is October 14, 2020. The invention further discloses application of the bacterial strain in aging resistance of animal bodies. The bacterial strain disclosed by the invention has the functions of enhancing the muscle strength, cognitive learning ability, reproductive capacity and antioxidant capacity of the animal bodies, and can be used for aging resistance of the animal bodies.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a bacterial strain with anti-aging function and its application. Background technique [0002] Aging is considered to be the weakening of the functions of various tissues of the body and the decline of the ability to adapt to the environment. This is a rather complex biological process, and its regulatory mechanism is still unclear. Research considers aging as the decline of individual genes or the immune system, where multiple processes combine and interact at many levels, not only at the cellular and molecular level, but also at the tissue and organ systems. [0003] One of the most prominent phenotypes of aging is the decline in skeletal muscle strength, which occurs in all aging individuals and leads to lower extremity dysfunction and loss of mobility. The decline in muscle strength was greater than the decline in muscle mass, suggesting that contractility per unit of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/742A61P39/06A61P21/00A61P25/28A61P15/08A23L33/135A23K10/18C12R1/07
CPCA61K35/742A61P39/06A61P21/00A61P25/28A61P15/08A23L33/135A23K10/18A23V2002/00A23V2200/302A23V2200/316A23V2200/30A23V2200/322
Inventor 束刚江青艳袁业现曾宇贤李金成
Owner SOUTH CHINA AGRI UNIV
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