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Establishment method and application of primary central nervous system lymphoma prognosis model

A technology for central nervous system and method for establishing a method is applied in the field of establishing a prognosis model of primary central nervous system lymphoma, which can solve the problem that the prognosis model is not necessarily applicable, and achieve the effect of precise stratified treatment.

Active Publication Date: 2021-09-24
CANCER CENT OF GUANGZHOU MEDICAL UNIV
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Problems solved by technology

[0005] The purpose of the present invention is to solve the technical problem that the above-mentioned existing prognosis model is not necessarily applicable to the new clinical treatment model of PCNSL, and to provide a primary Establishment method and application of prognosis model of central nervous system lymphoma

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  • Establishment method and application of primary central nervous system lymphoma prognosis model
  • Establishment method and application of primary central nervous system lymphoma prognosis model
  • Establishment method and application of primary central nervous system lymphoma prognosis model

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Embodiment Construction

[0034] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0035] Explanation of terms involved in the present invention:

[0036] PCNSL (primary central nervous system lymphoma): primary central nervous system lymphoma;

[0037] OS(overall survival): overall survival period;

[0038] ALC (absolute lymphocyte count): absolute lymphocyte count;

[0039] LDH (lactate dehydrogenase): lactate dehydrogenase;

[0040] LLR (lactate dehydrogenase-to-lymphocyte ratio): the ratio of lactate dehydrogenase to lymphocytes;

[0041] KPS score: Karnofsky (Karnofsky, KPS, percentage method) functional status score.

[0042] The predictive model involved in the present invention predicts patient OS, and OS is defined as the time from th...

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Abstract

The invention discloses a primary central nervous system lymphoma prognosis model. The prognosis model comprises related prognosis indexes, risk groups corresponding to different scores of the prognosis indexes and prognosis states corresponding to the risk groups. The prognosis indexes comprise at least two of the ratio of lactic dehydrogenase to lymphocyte, age and KPS score. According to the invention, the ratio of lactic dehydrogenase to lymphocyte, age and KPS score are integrated as prognosis evaluation indexes of primary central nervous system lymphoma for the first time, and a novel prognosis evaluation model for patients with primary central nervous system lymphoma is established.

Description

technical field [0001] The invention belongs to the technical field of biomedical detection, and in particular relates to a method for establishing a prognosis model of primary central nervous system lymphoma and its application. Background technique [0002] Primary central nervous system lymphoma (PCNSL) is a rare non-Hodgkin's lymphoma that occurs in the brain, spinal cord, meninges and eyes. Other organ systems are involved. The clinical diagnosis and treatment of PCNSL has always been a difficult point in the field of hematological malignancies, and its incidence has increased in recent years, especially in elderly patients over 60 years old. [0003] In the prior art, with the use of high-dose methotrexate, the survival of patients has been improved, but the therapeutic effect and prognosis of the disease are still unsatisfactory. International Extranodal Lymphoma Study Group (IELSG) score and Memorial Sloan Kettering Cancer Center (MSKCC) score are commonly used sco...

Claims

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Application Information

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IPC IPC(8): G16H50/20G16H70/40
CPCG16H50/20G16H70/40
Inventor 游华魏丽高玉婷
Owner CANCER CENT OF GUANGZHOU MEDICAL UNIV
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