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Application of GL-V9 as tumor immunomodulator

A technology of GL-V9, an immunomodulator, applied in the application field of the compound GL-V9 as a tumor immunomodulator, can solve the problems of decreased immunity, immunosuppression of the body, and the threat of tumor patients, and achieve the effect of promoting tumor immunity

Inactive Publication Date: 2021-08-13
CHINA PHARM UNIV
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Problems solved by technology

[0002] At present, the treatment methods for tumors mainly include surgery, chemotherapy, radiotherapy, immunotherapy and other treatment methods, but the process of surgery, radiotherapy and chemotherapy will lead to the decline of the body's immunity, and more seriously, it will also lead to the body's immunosuppression, making the remaining tumors Cells continue to exist and metastasize, posing a threat to cancer patients

Method used

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  • Application of GL-V9 as tumor immunomodulator
  • Application of GL-V9 as tumor immunomodulator
  • Application of GL-V9 as tumor immunomodulator

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Embodiment 1

[0040] Flow cytometric surface antigen detection

[0041] As the cells differentiate, the protein antigens on the surface of the cell membrane also change accordingly, and these proteins related to differentiation are called differentiation antigens. Whether cells are differentiated can be more accurately judged by detecting cell surface differentiation antigens. HLA-ABC and HLA-DR are type I and type II human leukocyte antigens expressed on the surface of human antigen-presenting cells, respectively. GL-V9 acted on human tumor cells and incubated them for a specified time to collect and count the cells, and adjust the cells in each group to the same density (5×10 5 cells / ml), the non-specific binding sites on the cell surface were blocked with PBS buffer containing 0.5% BSA, resuspended after centrifugation, and antibodies were added, and fluorescently labeled positive cells were counted by immunofluorescence flow cytometry (FCM), Cells treated in the same way without addin...

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Abstract

Research finds that a flavonoid derivative GL-V9 can significantly induce expression of antigen-presenting complex on the surface of tumor cells and enhance the potential of tumor cell immunity, which is further proved through a surface antigen detection experiment by a flow cytometer, indicating that the GL-V9 has the application potential of a tumor immunomodulator, and provides a new way and means for effectively treating tumors, especially human melanoma.

Description

technical field [0001] The invention belongs to the field of immunomodulators, and in particular relates to the application of a compound GL-V9 as a tumor immunomodulator. Background technique [0002] At present, the treatment methods for tumors mainly include surgery, chemotherapy, radiotherapy, immunotherapy and other treatment methods, but the process of surgery, radiotherapy and chemotherapy will lead to the decline of the body's immunity, and more seriously, it will also lead to the body's immunosuppression, making the remaining tumors The cells continue to exist and metastasize, posing a threat to tumor patients. The phenomenon that tumor cells survive and proliferate in vivo by evading the recognition and attack of the body's immune system through various mechanisms is called tumor immune escape. The body's immune system has the function of immune surveillance. When cancerous cells appear in the body, the immune system can recognize and specifically eliminate these ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4025A61P37/02A61P35/00
CPCA61K31/4025A61P37/02A61P35/00
Inventor 郭青龙惠慧李慧杨林周煜新魏立彬张小博徐澍吴焘高源
Owner CHINA PHARM UNIV
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