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A kind of crystalline form of propionamide derivatives and preparation method thereof

A technology of crystal form and compound, applied in the field of crystal form and preparation of propionamide derivatives, can solve the problems of difficult filtration, poor product stability, poor fluidity and the like

Active Publication Date: 2022-05-24
NHWA PHARMA CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Generally speaking, amorphous pharmaceutical products have no regular crystal structure and often have other defects, such as poor product stability, difficult filtration, easy agglomeration, poor fluidity, etc. These differences often lead to difficulties in production scale-up, so , it is necessary to improve all aspects of the properties of the compound through the crystal form, in-depth research to find a new crystal form with high purity and good chemical stability

Method used

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  • A kind of crystalline form of propionamide derivatives and preparation method thereof
  • A kind of crystalline form of propionamide derivatives and preparation method thereof
  • A kind of crystalline form of propionamide derivatives and preparation method thereof

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Embodiment Construction

[0069] In the specification and claims of the present application, unless otherwise specified, scientific and technical terms used herein have the meanings commonly understood by those skilled in the art. However, for a better understanding of the present invention, definitions and explanations of some related terms are provided below. In addition, when the definitions and explanations of terms provided in this application are inconsistent with the meanings commonly understood by those skilled in the art, the definitions and explanations of terms provided in this application shall prevail.

[0070] The "alcohols" in the present invention refer to one or more "hydroxyl groups" substituted for "C 1-6 A group derived from one or more hydrogen atoms on "alkyl", the "C 1-6 "Alkyl" is as defined above, and specific examples include, but are not limited to, methanol, ethanol, n-propanol, or isopropanol.

[0071] The "esters" mentioned in the present invention refer to compounds wit...

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Abstract

The present invention relates to a crystal form A of propionamide derivatives and a preparation method thereof. The crystal form A of the compound of formula (1) obtained in the present invention has good crystal form stability and chemical stability, and can be used better in clinical treatment.

Description

technical field [0001] The present invention relates to a crystalline form of propionamide derivatives and a preparation method thereof. Background technique [0002] Schizophrenia is the most serious and most damaging of all mental illnesses. The latest research shows that the social burden of mental illness ranks first among diseases in China. [0003] There are two main types of schizophrenia drugs: typical antischizophrenia drugs and atypical antischizophrenia drugs. Although typical antischizophrenic drugs (such as chlorpromazine and haloperidol) have good effects on positive symptoms of schizophrenia, they have adverse effects such as severe extrapyramidal reactions (EPS), tardive dyskinesia, and increased prolactin Although atypical antischizophrenic drugs (such as clozapine and risperidone) significantly reduce the occurrence of extrapyramidal reactions, adverse reactions such as QT interval prolongation and high prolactin still exist. [0004] After decades of re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D413/14C07D217/24C07D401/12A61K31/4725A61P25/18
CPCC07D413/14A61P25/28C07B2200/13A61P25/18A61K31/4725C07D413/12
Inventor 郝超
Owner NHWA PHARMA CORPORATION
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