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New application of potassium iodide or a composition containing potassium iodide in the preparation of medicines for treating African swine fever

A technology of African swine fever and potassium iodide, which is applied to the active ingredients of iodine compounds, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of not being able to inhibit the replication of HSV-1 virus, and achieve the reduction of virus titer and inhibition of replication Effect

Active Publication Date: 2022-01-14
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wherein literature (Melchjorsen J, et al.Early Innate Recognition of Herpes Simplex Virus in Human Primary Macrophages Is Mediated via the MDA5 / MAVS-Dependent and MDA5 / MAVS / RNAPolymerase III-Independent Pathways.) discloses RNA polymerase III inhibitor ML60218 to The levels of interferon IFN-β and TNF-α were not suppressed after HSV-1 infection, that is, ML60218 could not inhibit the replication of HSV-1 virus

Method used

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  • New application of potassium iodide or a composition containing potassium iodide in the preparation of medicines for treating African swine fever
  • New application of potassium iodide or a composition containing potassium iodide in the preparation of medicines for treating African swine fever
  • New application of potassium iodide or a composition containing potassium iodide in the preparation of medicines for treating African swine fever

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Example 1 Effect of KI and ML-60218 on African swine fever virus infection replication and gene transcription expression

[0035] 1. Changes in African swine fever virus infection and replication

[0036] Porcine alveolar macrophages (PAM, 1 × 10 6 / well), the experimental group was treated with KI (100 μM), ML-60218 (50 μM), KI (100 μM) and ML-60218 (50 μM) compositions for 2 hours, and then infected with ASFV CN / GS / 2018 strain (0.1MOI) 24h; Empty cells and empty cells were inoculated with ASFV CN / GS / 2018 strain (0.1MOI) for 24h as a control. Cells and supernatants from different treatments were collected, frozen and thawed three times at -80°C as samples, and serially diluted 10 times with serum-free RPMI 1640 to make 7 dilutions, each dilution repeated 8 wells, and inoculated into PAM Cells were cultured while porcine red blood cells were added; the cell plate was placed at 37°C, 5% CO 2 The conditions were cultured for 5 days, and the hematocyte adsorption reactio...

Embodiment 2

[0047] Example 2 Cytotoxicity of KI combined with ML-60218

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Abstract

The invention belongs to the technical field of treating African swine fever, and in particular relates to a new application of potassium iodide or a composition containing potassium iodide for preventing or treating African swine fever. The present invention unexpectedly finds that potassium iodide (KI) can inhibit the expression of African swine fever virus protein p72 and p30, inhibit the gene copy number and virus titer of African swine fever virus, can inhibit the replication and infection of ASFV, and is used for preventing or treating African swine fever At the same time, the present invention found that potassium iodide (KI) combined with ML-60218 can significantly inhibit the expression of African swine fever virus protein p30, p72, prevent the virus from invading host cells, and can be used to inhibit the entire period of ASFV infection; and potassium iodide (KI) Combined with ML‑60218, it can significantly inhibit the replication of African swine fever virus, reduce the virus titer after African swine fever virus infection, and can be used as an inhibitor of African swine fever virus to prevent or treat African swine fever.

Description

technical field [0001] The invention belongs to the technical field of treating African swine fever, and in particular relates to a new application of potassium iodide or a composition containing potassium iodide for preventing or treating African swine fever. Background technique [0002] African swine fever (African swine fever, ASF) is caused by the infection of African swine fever virus (ASFV), and is characterized by fever and hemorrhage in pigs. The fatality rate for domestic pigs is as high as 100%. . The disease first broke out in Kenya in 1921 and subsequently became widespread among domestic and wild pigs throughout Africa. It was introduced into Europe in the 1950s, and it took 40 years to eliminate the disease throughout Europe. However, the disease was introduced to Georgia from East Africa again in 2007, and then spread widely in Eastern Europe, and in 2017, it was introduced to Irkutsk in the Russian Far East. In early August 2019, researcher Hu Rongliang t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/18A61P31/20A61K31/4155
CPCA61K33/18A61K31/4155A61P31/20A61K2300/00
Inventor 郑海学李丹吴盼雪李玲霞杨文萍张敬朱国强茹毅田宏秦晓东冯涛杨帆张克山
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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