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Application of loureirin B in preparation of medicine for preventing and/or treating obesity

A technology for preparing medicines and dragon blood, which is used in drug combinations, metabolic diseases, active ingredients of ketones, etc.

Pending Publication Date: 2021-06-08
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about dragon blood B can prevent or treat obesity by promoting browning of white fat

Method used

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  • Application of loureirin B in preparation of medicine for preventing and/or treating obesity
  • Application of loureirin B in preparation of medicine for preventing and/or treating obesity
  • Application of loureirin B in preparation of medicine for preventing and/or treating obesity

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Experimental program
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Effect test

Embodiment

[0029] C57BL / 6J mice, male, 8 weeks old, 20-22 g, were purchased from the Department of Animals, Peking University Health Science Center.

[0030] Maintenance feed: purchased from the Department of Animals, Peking University Health Science Center.

[0031] High Fat Feed: Purchase with Boopac Corporation.

[0032] All animal experiments were strictly in accordance with the requirements of the "Guidelines for the Management and Use of Experimental Animals" and were approved by the Experimental Animal Management Committee of Peking University. Animals were sacrificed under anesthesia and with as little pain as possible.

[0033] Dragon blood B was provided by Shanghai Taosu Biochemical Technology Co., Ltd. Dragon blood B, molecular formula: C 18 h 20 o 5 , average molecular weight 316.35, poor water solubility.

[0034] 1. Experimental method:

[0035] 1. Male C57BL / 6 mice aged 6-8 weeks, feeding conditions: ambient temperature 22 degrees Celsius ± 0.5 degrees Celsius, 12 ...

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PUM

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Abstract

The invention discloses application of loureirin B in preparation of a medicine for preventing and / or treating obesity. Compared with the prior art, the invention discloses a novel medical application of the loureirin B, and finds that the loureirin B has an excellent effect of preventing and / or treating obesity. Researches show that loureirin B can significantly inhibit weight gain of obesity induced by high fat. And the loureirin B is mainly used for reducing the weight of fat and hardly affects lean body mass. In addition, the basic metabolic rate and the fat utilization rate of mice can be remarkably improved. The research on the molecular level shows that the loureirin B can obviously improve the expression of the browning molecular marker of the white adipose tissue and promote the browning of the white adipose tissue.

Description

technical field [0001] The invention belongs to the technical field of new medical application of dragon blood B, and in particular relates to the application of dragon blood B in the preparation of drugs for preventing and / or treating obesity. Background technique [0002] With the continuous improvement of people's living standards, obesity has become an important factor that seriously threatens public health in the 12th century. Obesity can cause a variety of metabolic diseases, such as dyslipidemia, type 2 diabetes mellitus (T2DM), and cardiovascular and cerebrovascular diseases, and even increase the incidence of certain cancers. In 2014, more than one third (39%) of adults worldwide were overweight, and more than 500 million adults were classified as obese. Such a high morbidity rate and multiple serious complications make obesity an urgent problem to be solved in contemporary society. Brown-like change of white adipose tissue, discovered in 2010, refers to the fact ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P3/04
CPCA61K31/12A61P3/04
Inventor 谢正伟郑瑞茂朱杰郭冰冰王昕
Owner PEKING UNIV
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