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Hapten of organophosphorus triazophos pesticide and preparation method thereof

A triazophos-like and organophosphorus-like technology, applied in the field of hapten and its preparation of organophosphorus triazophos-like pesticides, can solve the problems of organophosphorus pesticide residues, environmental pollution, threats to human health and ecological environment, etc.

Inactive Publication Date: 2021-06-04
INST OF VEGETABLE & FLOWERS CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the pesticide residues in agricultural products will not only cause environmental pollution, but also cause damage to human health.
Especially with the irregular use and abuse of organophosphorus pesticides, a large amount of organophosphorus pesticides are left on crops, which seriously threatens human health and the ecological environment.

Method used

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  • Hapten of organophosphorus triazophos pesticide and preparation method thereof
  • Hapten of organophosphorus triazophos pesticide and preparation method thereof
  • Hapten of organophosphorus triazophos pesticide and preparation method thereof

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preparation example Construction

[0044] According to one aspect of the present invention, the present invention relates to a method for preparing a hapten of organophosphorus triazophos pesticides, comprising the following steps:

[0045] A method for preparing a hapten of an organophosphorus triazophos pesticide, comprising the following steps:

[0046] (a) using 1-phenyl-3-hydroxyl-1,2,4-triazole as a raw material to obtain 1-p-nitrobenzene-3-hydroxyl-1,2,4-triazole through nitration reaction;

[0047] (b) Substituting the 1-p-nitrobenzene-3-hydroxyl-1,2,4-triazole obtained in step (a) and diethylphosphoryl thiochloride to obtain diethyl (1-p-nitrogen phenyl-3-hydroxy-1,2,4-triazole) phosphorothioate;

[0048](c) Diethyl (1-p-nitrobenzene-3-hydroxyl-1,2,4-triazole) phosphorothioate obtained in step (b) is subjected to a nitro reduction reaction to obtain diethyl (1 - p-aminobenzene-3-hydroxy-1,2,4-triazole) phosphorothioate;

[0049] (d) Diethyl (1-p-aminobenzene-3-hydroxyl-1,2,4-triazole) phosphorothioa...

Embodiment 1

[0088] A preparation method of organophosphorus triazophos pesticide hapten, comprising the following steps:

[0089] (a) Add 6.0g of 1-phenyl-3-hydroxy-1,2,4-triazole into 50mL of concentrated sulfuric acid, add 2.6g of fuming nitric acid dropwise to the reaction solution at 0°C, and the addition is complete Finally, at 0°C, the reaction solution was stirred for 5 hours; figure 1 LCMS detection showed that the raw materials were consumed completely, and a product peak was generated; the 1-p-nitrobenzene-3-hydroxyl-1,2,4-triazole reaction solution was poured into ice water, and the precipitated solid was filtered first, and then dissolved in ethyl acetate After ester beating, filter to obtain light yellow solid 1-p-nitrobenzene-3-hydroxyl-1,2,4-triazole compound; 1-p-nitrobenzene-3-hydroxyl-1,2,4-triazole compound is 5.0g, the yield is 65%;

[0090] (b) 5.0g 1-p-nitrobenzene-3-hydroxyl-1,2,4-triazole, 3.7g triethylamine (Et 3 N), 0.3g 4-dimethylaminopyridine (DMAP) and 6.0g...

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Abstract

The invention relates to the technical field of immunochemical analysis and pesticide residue detection, in particular to a hapten of an organophosphorus triazophos pesticide and a preparation method of the hapten. According to the preparation method, 1-phenyl-3-hydroxy-1, 2, 4-triazole serves as a raw material, and the hapten of the organophosphorus triazophos pesticide is synthesized through nitration reaction, substitution reaction, reduction reaction and carboxyl active group introduction reaction. Therefore, the antibody with high specificity and high affinity to organophosphorus pesticides can be prepared.

Description

technical field [0001] The invention relates to the technical field of immunochemical analysis and pesticide residue detection, in particular to a hapten of organophosphorus triazophos pesticide and a preparation method thereof. Background technique [0002] The quality and safety of agricultural products affect people's health, and have attracted more and more attention. Among them, pesticide residues in agricultural products will not only cause environmental pollution, but also cause damage to human health. Especially with the irregular use and abuse of organophosphorus pesticides, a large amount of organophosphorus pesticides are left on crops, which seriously threatens human health and the ecological environment. Therefore, it is an urgent scientific research problem to develop a rapid immunoassay method for pesticide residues in agricultural products with high sensitivity and low detection limit. Strengthening the research on triazophos detection method is of great sig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/6518
CPCC07F9/6518
Inventor 徐东辉刘广洋陈鸽林桓高宇航高明坤田明硕张延国
Owner INST OF VEGETABLE & FLOWERS CHINESE ACAD OF AGRI SCI
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