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7-Diethylamino-3-acetylcoumarin derivatives and their synthetic methods and applications

A technology based on coumarin and diethylamino, which is applied in the field of 7-diethylamino-3-acetylcoumarin derivatives, can solve the problems of less research and achieve good selectivity, simple detection means, low cost effect

Active Publication Date: 2022-05-31
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, relatively little research has been done on the 4-position of 7-diethylamino-3-acetylcoumarin

Method used

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  • 7-Diethylamino-3-acetylcoumarin derivatives and their synthetic methods and applications
  • 7-Diethylamino-3-acetylcoumarin derivatives and their synthetic methods and applications
  • 7-Diethylamino-3-acetylcoumarin derivatives and their synthetic methods and applications

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Embodiment 1

Embodiment 2

[0044] The fluorescent probe stock solution of 2mM Probe 2 is prepared with dimethyl sulfoxide (DMSO); 2mL of PBS (pH=7.4)

Embodiment 3

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Abstract

The invention provides a 7-diethylamino-3-acetyl coumarin derivative and its synthesis method and application, the derivative is 4-(3-(7-(diethylamino)-2- Oxo-2H-chromium-3-yl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-yl)benzoic acid, the English name is 4-(3-(7- (diethylamino)‑2‑oxo‑2H‑chromen‑3‑yl)‑5‑(p‑tolyl)‑4,5‑dihydro‑1H‑pyrazol‑1‑yl) benzoic acid, named Probe 1; or 4 ‑(3‑(7‑(diethylamino)‑4‑hydroxy‑2‑oxo‑2H‑chromium‑3‑yl)‑5‑(p-tolyl)‑4,5‑dihydro‑1H‑pyrazole ‑1‑yl)benzoic acid, the English name is 4‑(3‑(7‑(diethylamino)‑4‑hydroxy‑2‑oxo‑2H‑chromen‑3‑yl)‑5‑(p‑tolyl)‑4, 5‑dihydro‑1H‑pyrazol‑1‑y l)benzoic acid, named Probe 2. In PBS (pH=7.4) buffer solution, Probe 1 and ClO ‑ No reaction, Probe 2 can realize "turn-off" detection of ClO ‑ . The detection process is simple, sensitive and fast, and the detection result is accurate.

Description

7-diethylamino-3-acetyl coumarin derivative and its synthetic method and application technical field The present invention relates to 7-diethylamino-3-acetyl coumarin derivatives, specifically belong to 7-diethylamino-3-acetyl Coumarin derivative and synthetic method thereof, and the derivative as detection reagent in detecting ClO ‑ applications in . Background technique Coumarin is widely used in the field of chemical biology probes because of its advantages such as easy modification of its structure and diverse photophysical properties. considerable development. Coumarin is a dye with a benzopyrone structure that is not inherently fluorescent. Introduced in 3rd and 4th place The introduction of electron-donating groups or electron-withdrawing groups at the 6 and 7 positions will produce strong fluorescence. Coumarin dyes have larger Stokes bits migration, good water solubility and high quantum yield. Due to the small size of coumarin dyes and their ability...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D405/04C09K11/06G01N21/64A61K49/00
CPCC07D405/04C09K11/06G01N21/6428A61K49/0039C09K2211/1088C09K2211/1044C09K2211/1007Y02A50/30
Inventor 黄永飞阴彩霞张永斌霍方俊
Owner SHANXI UNIV
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