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A kind of betel nut extract for improving gastric motility and its preparation process and application

A preparation process and extract technology, applied in betel nut extract and its preparation process and application field, can solve the problems of poor transfer rate of active ingredients, affecting drug safety, affecting drug activity, etc., to reduce the residual rate of phenol red, Good gastric emptying effect, enhanced activity and safety effects

Active Publication Date: 2022-02-18
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing extraction methods, the transfer rate of active ingredients such as arecoline, arecoline, polyphenols, etc. is not good, and there are heavy metal residues, which affect the activity of the drug and affect the safety of the drug

Method used

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  • A kind of betel nut extract for improving gastric motility and its preparation process and application
  • A kind of betel nut extract for improving gastric motility and its preparation process and application
  • A kind of betel nut extract for improving gastric motility and its preparation process and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1-betel nut extract

[0023] Take the fried betel nut Chinese medicinal material and crush it, use ether, ethanol, and chloroform as the extraction solvent in a volume ratio of 1:0.2:0.03, the mass volume ratio of the crushed betel nut to the extraction solvent kg / L is 1:8, and then add the Carbonate buffer solution, the volume ratio of the extraction solvent to the carbonate buffer solution is 100:5, shake and extract at 140rpm for 40 minutes, then heat and reflux for 20 minutes, collect the extract, repeat the reflux extraction 3 times, and combine The total extract is added with a composite adsorbent, the mass volume ratio of the composite adsorbent to the total extract kg / L is 1:10, and the composite adsorbent is composed of chitosan, diatomaceous earth and 1. Prepared by activated carbon, let it stand for 15 minutes; filter, concentrate the filtrate under reduced pressure at 60-70°C to form a thick paste, and dry it to obtain it.

Embodiment 2

[0024] The preparation of embodiment 2-betel nut extract

[0025] Take the fried betel nut Chinese medicinal material and crush it, use ether, ethanol, and chloroform as the extraction solvent in a volume ratio of 1:0.3:0.05, the mass volume ratio kg / L of the betel nut to the extraction solvent after crushing is 1:12, and then add Carbonate buffer solution, the volume ratio of the extraction solvent to the carbonate buffer solution is 100:7, shake and extract at 160rpm for 20 minutes, then heat and reflux for 40 minutes, collect the extract, repeat the reflux extraction 3 times, and combine The total extract is added with a composite adsorbent, the mass volume ratio of the composite adsorbent to the total extract kg / L is 1:12, and the composite adsorbent is composed of chitosan, diatomaceous earth and , prepared by activated carbon, let it stand for 20 minutes; filter, concentrate the filtrate under reduced pressure at 60-70°C to form a thick paste, and dry it to obtain it.

Embodiment 3

[0026] The preparation of embodiment 3-betel nut extract

[0027] Take the fried betel nut Chinese medicinal material and crush it, use ether, ethanol, and chloroform as the extraction solvent in a volume ratio of 1:0.28:0.04, and the mass volume ratio kg / L of the betel nut to the extraction solvent after crushing is 1:10, and then add Carbonate buffer solution, the volume ratio of the extraction solvent to the carbonate buffer solution is 100:6, shake and extract at 150rpm for 30 minutes, then heat and reflux for 30 minutes, collect the extract, repeat the reflux extraction 3 times, and combine The total extract is added with a composite adsorbent, the mass volume ratio of the composite adsorbent to the total extract kg / L is 1:10, and the composite adsorbent is composed of chitosan and diatomite with a mass ratio of 1:0.07:0.15 1. Prepared by activated carbon, let it stand for 18 minutes; filter, concentrate the filtrate under reduced pressure at 60-70°C to form a thick paste...

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Abstract

The present invention provides an extract of betel nut for improving gastric motility and its preparation process and application. The preparation process includes the following steps: take fried betel nut Chinese medicinal material and crush it, and use ether, ethanol, and chloroform in a volume ratio of 1:0.2-0.3:0.03- 0.05 as the extraction solvent, then add carbonate buffer, shake for 20-40 minutes, heat and reflux for 20-40 minutes, collect the extract, repeat the reflux extraction for 2-3 times, combine the total extract, add composite adsorption agent, the composite adsorbent is made of chitosan, diatomaceous earth, and activated carbon, and left to stand for 15-20min; filtered, and the filtrate is concentrated under reduced pressure at 60-70°C to form a thick paste, dried, and obtained. The betel nut extract obtained by the present invention not only significantly improves the transfer rate of arecoline, arecoline, and areca nut polyphenols, but also effectively removes heavy metals such as lead, arsenic, and mercury, improves the activity and safety of the areca nut extract, and can significantly reduce phenols in the stomach of mice. Red residual rate, has a good gastric emptying effect, can be better used in the preparation of drugs to improve gastric motility.

Description

technical field [0001] The invention relates to the technical field of natural medicine extraction, in particular to a betel nut extract for improving gastric motility and its preparation process and application. Background technique [0002] The Chinese herbal medicine of fried betel nut is the dry mature seed of Areca catechu L., a palm plant. Stir fry until yellow. Betel nut contains alkaloids, polyphenols and fatty acids, etc. The alkaloids are mainly arecoline, and the rest are arecoline. In the existing extraction methods, the transfer rate of active ingredients such as arecoline, arecoline, and polyphenols is not good, and there are heavy metal residues, which affect the activity of the drug and affect the safety of the drug. Contents of the invention [0003] In view of this, the present invention proposes a betel nut extract for improving gastric motility and its preparation process and application, so as to solve the above-mentioned technical problems. [0004...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/889A61P1/14A61K131/00
CPCA61K36/889A61P1/14A61K2236/333A61K2236/35A61K2236/53A61K2236/51Y02A50/30
Inventor 刘景萍刘全国陈克领王家李党吴伟贞吴育强
Owner HAINAN HULUWA PHARMA GRP CO LTD
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