Sugar chain structure analysis device and sugar chain structure analysis program

A technology for structure analysis and sugar chain, which is applied in the fields of sugar chain structure analysis devices and programs for sugar chain structure analysis, and can solve problems such as time-consuming, increased retrieval objects, and time-consuming problems.

Pending Publication Date: 2021-05-14
SHIMADZU SEISAKUSHO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At this time, in order to increase the number of search objects, it is necessary to change the search conditions and perform multiple searches, which will consume a lot of work and time.
In addition, the additional input setting of modifiers is not only time-consuming, but also has the problem of easily causing wrong settings

Method used

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  • Sugar chain structure analysis device and sugar chain structure analysis program
  • Sugar chain structure analysis device and sugar chain structure analysis program
  • Sugar chain structure analysis device and sugar chain structure analysis program

Examples

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Embodiment Construction

[0061] First, a sugar chain structure analysis system as an embodiment of the present invention will be described with reference to the drawings.

[0062] figure 1 It is a schematic block diagram of the sugar chain structure analysis system of this example. like figure 1 As shown, this system includes a mass spectrometry unit 1 for performing measurement on a sample, a data analysis unit 2 for performing analysis processing, and an input unit 3 and a display unit 4 as user interfaces. The data analysis unit 2 includes a data storage unit 21, a peak detection unit 22, and a sugar chain structure analysis unit 23, and the sugar chain structure analysis unit 23 includes an analysis condition setting unit 24, a sugar chain core structure quality calculation unit 25, and a sugar chain theory analysis unit 23. The mass-to-charge ratio calculation unit 26, the sugar chain structure estimation unit 27, and the estimation result display processing unit 28 serve as functional blocks...

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Abstract

In a sugar chain structure analysis device according to an embodiment of this invention, one of a plurality of tabs for setting analysis conditions is dedicated to setting conditions relating to sialic-acid-binding-mode-specific chemical modification, and a user is able to select primary chemical modification reagents. When the reagents are selected, mass changes are automatically set for each binding mode. Further, when a chemical modification other than a predetermined chemical modification is used, the user may numerically input mass change amounts for each binding mode. During analysis, for one chemical modification, the theoretical m / z values of a plurality of sugar chain candidates having m / z values that vary according to the binding mode and the actually measured ion peak m / z values are compared collectively. As a result, when the structure of a sugar chain including a sialic-acid binding mode is analyzed through chemical modification using sialic-acid-binding-mode-specific chemical modification reagents, it is possible to reduce analysis-related user work and improve analysis efficiency.

Description

technical field [0001] The present invention relates to a sugar chain structure analysis device for analyzing sugar chain structures by mass spectrometry, and a sugar chain structure analysis program for analyzing sugar chain structures on a computer. Sugar chain structure analysis device for sugar chain structure analysis including sialic acid linkage method, and sugar chain structure analysis program. It should be noted that the "sugar chain" referred to here includes not only sugar chains that exist alone, but also sugar chains in the state of modifying biomolecules such as proteins, peptides, lipids, and nucleic acids, that is, modified sugar chains. Background technique [0002] The biosynthesis process of biomolecules such as proteins and peptides in organisms is finely regulated. Therefore, it is increasingly believed that sugar chain-modified biomolecules produced through biosynthesis play an important role in life activities. specific reports. From this current s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62
CPCH01J49/0036G16C20/20G16B40/10
Inventor 村瀬雅树西风隆司
Owner SHIMADZU SEISAKUSHO CO LTD
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