Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Method for determining related substances of 6-acetoxy-7-methoxy-3H-quinazoline-4-ketone

A technology of acetoxy and related substances, applied in the field of drug analysis and detection, can solve problems such as low sensitivity, poor detection quality, and complicated operation

Inactive Publication Date: 2021-04-30
南京百泽医药科技有限公司
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, after the drug is produced, it is necessary to detect the substance of 6-acetoxy-7-methoxy-3H-quinazolin-4-one to confirm that 6-acetoxy-7-methoxy - the effects and characteristics of 3H-quinazolin-4-one drugs, yet, when the existing detection method detects 6-acetoxy-7-methoxyl-3H-quinazolin-4-one drugs, its Impurities are similar in structure and difficult to separate, and cannot quickly detect the content of each impurity in 6-acetoxy-7-methoxy-3H-quinazolin-4-one. The operation is complicated and the sensitivity is low, so it cannot be detected well Mass in 6-acetoxy-7-methoxy-3H-quinazolin-4-one

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for determining related substances of 6-acetoxy-7-methoxy-3H-quinazoline-4-ketone
  • Method for determining related substances of 6-acetoxy-7-methoxy-3H-quinazoline-4-ketone
  • Method for determining related substances of 6-acetoxy-7-methoxy-3H-quinazoline-4-ketone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0038] structure:

[0039] 6-Acetoxy-7-methoxy-3H-quinazolin-4-one

[0040]

[0041] BZP00231:

[0042]

[0043] BZP00240:

[0044]

[0045] BZP00241:

[0046]

[0047] The invention provides a method for determining related substances of 6-acetoxy-7-methoxy-3H-quinazolin-4-one, such as Figure 1-3 As shown, usi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for determining related substances of 6-acetoxy-7-methoxy-3H-quinazoline-4-ketone. The metohd adopts fluorophenyl silane bonded silica gel as a filler and a potassium dihydrogen phosphate buffer acetonitrile mixed solution as a mobile phase, gradient elution is carried out, and a sample solvent is an acetonitrile aqueous solution. The detection method is accurate, simple and convenient to operate, good in reproducibility, good in sensitivity and specificity, capable of meeting detection of related substances of an antitumor drug gefitinib starting material 6-acetoxyl-7-methoxy-3H-quinazoline-4-ketone, capable of well controlling special impurities in a sample, capable of ensuring the product quality and high in practicability in work.

Description

technical field [0001] The invention belongs to the technical field of drug analysis and detection, and in particular relates to a method for determining related substances of 6-acetoxy-7-methoxy-3H-quinazolin-4-one. Background technique [0002] 6-Acetoxy-7-methoxy-3H-quinazolin-4-one is an important starting material of gefitinib, so its related substances need to be controlled to ensure the quality of the finished product. Gefitinib is mainly aimed at patients with advanced lung adenocarcinoma with epidermal growth factor receptor positive. pathway, can play an inhibitory role, and is mainly suitable for the first-line treatment of patients with advanced lung adenocarcinoma epidermal growth factor receptor positive. [0003] At present, after the drug is produced, it is necessary to detect the substance of 6-acetoxy-7-methoxy-3H-quinazolin-4-one to confirm that 6-acetoxy-7-methoxy - the effects and characteristics of 3H-quinazolin-4-one drugs, yet, when the existing det...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N30/06G01N30/74
CPCG01N30/06G01N30/74
Inventor 陈文芝李静崔雍堃
Owner 南京百泽医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com