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Gel for treating inflammatory acne based on chitosan and preparation method of gel

A chitosan and inflammatory technology, applied in the field of gels based on chitosan for the treatment of inflammatory acne, can solve the problems of poor treatment effect of inflammatory acne wounds, no antioxidant function, poor bacteriostatic and anti-inflammatory effects, etc. , to achieve the effect of promoting wound healing, prevention and scar formation, and good coating effect

Inactive Publication Date: 2021-04-06
JIANGSU NEWVALUE MEDICAL PROD CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Poor antibacterial and anti-inflammatory effects, no anti-oxidation function, and poor therapeutic effect on inflammatory acne wounds, resulting in poor wound healing effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A gel for treating inflammatory acne based on chitosan, its formula composition is as follows: 10 parts of water, 2 parts of ethanol, 2 parts of propylene glycol, 3 parts of glycerin, 2 parts of butanediol, acryloyldimethyl taurine 10 parts of ammonium acid / VP copolymer, quaternary ammonium salt-733 parts, 1 part of o-cymene-5-ol, 3 parts of chitosan, 1 part of salicylic acid, 2 parts of papain and EDTA Disodium is 20 parts.

[0029] Humectants include propylene glycol, glycerin and butylene glycol, film former is ammonium acryloyldimethyl taurate / VP copolymer, anti-inflammatory agent is salicylic acid, chelating agent is disodium EDTA, chitosan is carboxymethyl Chitosan-based, molecular weight 2.9x10 4 Dalton, the degree of deacetylation is 60%, and the degree of carboxymethyl substitution is 60%.

[0030] The present invention also provides a preparation method of gel for treating inflammatory acne based on chitosan, comprising the steps of:

[0031] S1. Add quater...

Embodiment 2

[0036] A gel for treating inflammatory acne based on chitosan, its formula is composed as follows: 12.5 parts of water, 3 parts of ethanol, 3.5 parts of propylene glycol, 5 parts of glycerin, 3.5 parts of butanediol, acryloyldimethyl taurine Ammonium acid / VP copolymer is 13 parts, quaternary ammonium salt-734.5 parts, o-cymene-5-ol 2.5 parts, chitosan 4 parts, salicylic acid is 1.5 parts, papain 2.5 parts and EDTA Disodium is 26 parts.

[0037] Humectants include propylene glycol, glycerin and butylene glycol, film former is ammonium acryloyldimethyl taurate / VP copolymer, anti-inflammatory agent is salicylic acid, chelating agent is disodium EDTA, chitosan is carboxymethyl Chitosan-based, molecular weight 2.0x10 4 Dalton, the degree of deacetylation is 70%, and the degree of carboxymethyl substitution is 90%.

[0038] The present invention also provides a preparation method of gel for treating inflammatory acne based on chitosan, comprising the steps of:

[0039] S1. Add qu...

Embodiment 3

[0044] A gel for treating inflammatory acne based on chitosan, its formula composition is as follows: 15 parts of water, 4 parts of ethanol, 4 parts of propylene glycol, 7 parts of glycerin, 5 parts of butanediol, acryloyldimethyl taurine 16 parts of ammonium acid / VP copolymer, 736 parts of quaternary ammonium salt, 4 parts of o-cymene-5-ol, 5 parts of chitosan, 2 parts of salicylic acid, 3 parts of papain and EDTA Disodium is 30 parts.

[0045] Moisturizers include propylene glycol, glycerin and butylene glycol, film formers are ammonium acryloyldimethyl taurate / VP copolymer, anti-inflammatory agents are salicylic acid, chelating agents are disodium EDTA, chitosan is carboxyethyl Chitosan based, molecular weight 1.0x10 4 Dalton, the degree of deacetylation is 65%, and the degree of carboxyethyl substitution is 70%.

[0046] The present invention also provides a preparation method of gel for treating inflammatory acne based on chitosan, comprising the steps of:

[0047]S1. ...

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Abstract

The invention discloses gel for treating inflammatory acne based on chitosan and a preparation method of the gel. The formula of the gel comprises the following components in parts by weight: water, ethanol, a humectant, a film-forming agent, quaternary ammonium salt-73, o-cymene-5-alcohol, chitosan, an anti-inflammatory agent, papain and a chelating agent. The preparation method comprises the steps of adding quaternary ammonium salt-73, o-cymene-5-alcohol, chitosan and papain into water and ethanol, adding the humectant and the anti-inflammatory agent into the solution, continuously stirring, adding the film-forming agent and the chelating agent, and continuously stirring to be uniform so as to obtain the gel. The gel has the effects of inhibiting bacteria, diminishing inflammation and resisting oxidation, and can be used for treating inflammatory acne wounds, promoting wound healing and preventing and reducing scar formation.

Description

technical field [0001] The invention belongs to the technical field of acne treatment, in particular to a chitosan-based gel for treating inflammatory acne. Background technique [0002] Carboxymethyl chitosan is a water-soluble chitosan derivative with many properties, such as strong antibacterial, fresh-keeping effect, and an amphoteric polyelectrolyte. It has many applications in cosmetics, fresh-keeping, medicine, etc. It is also one of the chitosan derivatives that have been studied more in recent years. [0003] The carboxymethyl group of carboxymethyl chitin is substituted on the C6-OH of the sugar residue, and a small amount of carboxymethyl group is substituted on the C3-OH, resulting in O-carboxymethyl chitin. In chitosan, the carboxymethyl group will be substituted on both -OH and -NH to generate O-carboxymethyl and N-carboxymethyl chitosan. The actual substitutions are: C6 -O-carboxymethyl, C2-N-carboxymethyl, C3-O-carboxymethyl, C6-O, C2-N-carboxymethyl, etc. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K9/06A61K47/18A61K47/32A61P17/10A61P17/02A61K31/045A61K31/047A61K31/785A61K31/427A61K31/05A61K31/722A61K31/60
CPCA61K31/045A61K31/047A61K31/785A61K31/427A61K31/05A61K31/722A61K31/60A61K38/4873A61K9/06A61K9/0014A61K47/183A61K47/32A61P17/10A61P17/02C12Y304/22002A61K2300/00
Inventor 龚祖光梅琳
Owner JIANGSU NEWVALUE MEDICAL PROD CO LTD
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