Clean in-phase layer selection in-core selective coherence spectrum method

A technology of nuclear selectivity and selectivity, which is applied in the field of nuclear magnetic resonance of layer-selective homonuclear selective coherent spectrum, can solve the problems of consuming experiment time and difficulty in spectrum analysis, achieve clear spectrum, reduce experiment time, and avoid signal self-cancelling effect

Active Publication Date: 2021-03-30
XIAMEN UNIV +1
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Problems solved by technology

However, since the final signal is composed of the in-phase component and the anti-phase component, when the positive and negative signals are close to each other, the resulting self-cancellation makes spectrogram analysis difficult
In addition, the "soft" COZY experiment with non-parallel sampling can only measure the coupling relationship between one excited nucleus and one observed nucleus at a time, which will consume double the experimental time when measuring all the coupling situations of a given proton in the sample

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  • Clean in-phase layer selection in-core selective coherence spectrum method
  • Clean in-phase layer selection in-core selective coherence spectrum method
  • Clean in-phase layer selection in-core selective coherence spectrum method

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Embodiment Construction

[0022] Below in conjunction with accompanying drawing and embodiment, the present invention will be further described:

[0023] The invention provides a clean and homogeneous layer-selected homonuclear selective coherence spectrum method, which is characterized in that it comprises the following steps:

[0024] 1) collecting the NMR one-dimensional spectrum of the sample;

[0025] 2) Measure the pulse width of the 180-degree hard pulse of the sample;

[0026] 3) Measure the pulse width and time of the sample's excitation nuclear 90-degree selective pulse, observation nuclear 90-degree selective pulse, and inversion 90-degree selective pulse;

[0027] 4) Set dephasing gradient G 1 , G 2 and G 3 the intensity and duration of

[0028] 5) Set the central position of the excited hydrogen nucleus to be studied as the center frequency of the selective 90-degree selective pulse of the excited nucleus, and set the central position of the observed hydrogen nucleus to be studied as ...

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Abstract

The invention provides a clean in-phase layer selection in-core selective coherence spectrum method. A modified perfect echo module is used for achieving coherent transfer between the same phases, unwanted signals are removed in combination with selective pulses and phase removing gradients, only J coupling modulation signals generated when t1 and t2 are modulated by cosine functions of an excitation core and an observation core are finally reserved, and the signal strength is affected by a delta value. The two-dimensional J coupling modulation of the excitation core and the observation core presents an in-phase square in a spectrogram, the coupling information of the observation core and other cores is embodied on the lateral offset of the square, and the coupling information of the excitation core and other cores is embodied on the longitudinal offset of the square at present, and the modulation causing transverse and longitudinal offset is cosine modulation, so that the property that the spectral peak is in-phase is not influenced.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance method, in particular to a nuclear magnetic resonance method with clean and homogeneous layer-selective homonuclear selective coherence spectrum. Background technique [0002] NMR spectroscopy is a powerful analytical tool with a wide range of applications. J-coupling is an important parameter in NMR spectroscopy, which can provide valuable information about molecular structure and conformation. Among them, two-dimensional correlation spectroscopy (“COSY”) experiments that provide molecular J-coupling relationships play an indispensable role in molecular resolution, but their numerical resolution has been low due to the limited number of sampling points in the indirect dimension. Numerical resolution can be improved by a selective ("soft") COZY method, which facilitates the analysis of the coupling constant between a given proton and its coupled pair. However, since the final signal is composed of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N24/08
CPCG01N24/08
Inventor 林雁勤董曦曾庆
Owner XIAMEN UNIV
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