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New application of AZ191 in medicines

A technology of AZ191, 1.AZ191, applied in the field of new drug use of AZ191, can solve the problem of endogenous cardiomyocyte proliferation without AZ191

Active Publication Date: 2021-03-19
SYNOGENBIOPHARMACO LTD NANJING CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report on the induction of endogenous cardiomyocyte proliferation by AZ191.

Method used

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  • New application of AZ191 in medicines
  • New application of AZ191 in medicines
  • New application of AZ191 in medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0047] Test results such as figure 1 shown. Depend on figure 1 It can be seen that after AZ191 treatment, mAG-hGeminin (1 / 110) positive cardiomyocytes increased by 1.8 times compared with the blank control group (0.5% FBS+DMSO). Mean±SEM; **P<0.01. Example 2. In vitro test of AZ191 promoting neonatal rat cardiomyocytes to enter the cell cycle

[0048] Isolate rat cardiomyocytes born 3 days old, add AZ191 (final concentration in the culture medium is 10 μmol / l), use DMEM+DMSO as the control (control), wash three times with PBS after 48 hours, 4% PFA (paraformaldehyde) Fix at room temperature for 15 min, wash with PBS three times, block with 1% BSA / PBS / 0.1% Triton at room temperature for 1 h, add primary antibody after 1 h: Anti-α-Actinin (1:300, sigma, mouse, A7811), Phospho-Histone H3 (Ser10 ) Antibody (1:300, CST, rabbit, 9701S), Anti-Ki67 (1:300, abcam, rabbit, ab15580) overnight at 4°C, wash 4 times with 1% BSA / PBS / 0.02% Tween, add secondary antibody: Goat anti-rabbit ...

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Abstract

The invention discloses a new application of AZ191 in medicines. The new application is an application of AZ191 or pharmaceutically acceptable salt thereof in preparation of medicines for promoting proliferation of myocardial cells. Experiments prove that AZ191 can promote proliferation of myocardial cells of rats. Therefore, AZ191 can be used in the related fields of preparation of medicines forpromoting myocardial cell proliferation, medicines for treating or preventing heart diseases and the like, and a new medicine and a new treatment idea are provided for treating or preventing heart diseases such as myocardial infarction.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new drug application of AZ191. Background technique [0002] At present, cardiovascular disease has become the number one killer threatening human health. There are 40 million heart failure patients worldwide, and it has become the main cause of human death. Studies have found that cardiomyocytes in mammals gradually lose their ability to proliferate after adulthood. Once myocardial infarction occurs, the loss of cardiomyocytes will be irreversible. There are about 2-4 billion cardiomyocytes in an adult, about 25% of cardiomyocytes will be lost within a few hours after myocardial infarction, and the remaining cardiomyocytes have very limited proliferation ability, which is not enough to restore the contractile function of the heart, and the patient will eventually suffer from heart failure die. To solve this problem, in addition to surgery, basic translational research mai...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61P9/10A61P9/00A61P9/04
CPCA61K31/506A61P9/10A61P9/00A61P9/04
Inventor 卜晔杜建勇郑丽霞吴青朱小君熊敬维
Owner SYNOGENBIOPHARMACO LTD NANJING CHINA
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