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Nitrate-containing composition and application thereof

A technology of nitrate and composition, applied in the field of nitrate-containing composition, can solve the problems of increasing endometrial cancer and cardiovascular diseases, and achieve the effect of alleviating the decline

Active Publication Date: 2021-03-12
AIXI BEIJING INT CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs for the clinical treatment of osteoporosis can be divided into anti-bone resorption drugs, bone formation-promoting drugs and bone mineralization-promoting drugs, among which the most commonly used is estrogen replacement therapy (ERT). Well established, however, long-term use of estrogen increases the risk of endometrial cancer, breast cancer, and cardiovascular disease
[0003] At present, there are no studies or patents reporting the application of nitrate diet in the prevention and treatment of osteoporosis

Method used

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  • Nitrate-containing composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Refer to Table 1:

[0047] Table 1 Raw materials of the compositions of the present invention

[0048]

[0049]The corresponding amount of sodium nitrate, vitamin C and arginine were referred to, respectively, and the sodium nitrate, vitamin C and arginine were dissolved, 0.22 μm microporous filter filtration and sterilization, and the mixed solution was mounted. In a sterile Willin bottle, seal, -20 ~ -60 ° C freezing 2 to 12 h, freeze drying machine: set -20 ~ 20 ° C next time sublimation 4 ~ 20h, 20 ~ 40 ° C Second sub-sublimation 1 To 24h, the composition was obtained.

Embodiment 2

[0051] Refer to Table 2 for raw materials.

[0052] Table 2 Raw materials of the compositions 9 to 14 of the present invention

[0053]

[0054] The corresponding amount of sodium nitrate, vitamin B12, and arginine were referred to, respectively, the sodium nitrate, vitamin B12 and arginine were dissolved, 0.22 μm microporous filter filtration and sterilization, and the mixed solution was mounted. In a sterile Willin bottle, seal, -20 ~ -60 ° C freezing 2 to 12 h, freeze drying machine: set -20 ~ 20 ° C next time sublimation 4 ~ 20h, 20 ~ 40 ° C Second sub-sublimation 1 To 24h, the composition was obtained.

Embodiment 3

[0056] Refer to Table 3.

[0057] Table 3 Raw materials of the compositions 9 to 14 of the present invention

[0058]

[0059] The corresponding amount of potassium nitrate, vitamin C and arginine were referred to, respectively, and the potassium nitrate, vitamin C and arginine were dissolved, 0.22 μm microporous filter filtration and sterilization, and the mixed solution was mounted. In a sterile Willin bottle, seal, -20 ~ -60 ° C freezing 2 to 12 h, freeze drying machine: set -20 ~ 20 ° C next time sublimation 4 ~ 20h, 20 ~ 40 ° C Second sub-sublimation 1 To 24h, the composition was obtained.

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PUM

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Abstract

The invention provides a nitrate-containing composition and application thereof, which belong to the technical field of osteoporosis prevention and treatment. The composition comprises the following raw materials: nitrate, vitamins and arginine. The composition disclosed by the invention can remarkably relieve reduction of bone mineral density, bone volume fraction, bone trabecula thickness and bone trabecula number of an organism and remarkably recover lost bone mass of the organism. The composition disclosed by the invention can be applied to prevention and / or treatment of bone metabolic diseases, and also has a reference significance for treatment of diseases such as stem cell abnormality and immunologic abnormality.

Description

Technical field [0001] The present invention relates to the field of osteoporosis prevention and treatment, and more particularly to a composition containing nitrate and its application thereof. Background technique [0002] Osteoporosis is an elderly, especially the most common degenerative osteotransic diseases in menopausal women. Reduced systemic bone volume, fracture of bone tissue, decreased bone strength, increased bone, and fracture Systemic pain is the main lesion characteristics. At present, the clinical treatment of osteoporosis can be divided into antibiotic absorbent drugs, promoting bone formation drugs and promotes bone mineral drug, etc., which is most commonly used in estrogen replacement therapy, Ert), and its efficacy has It is fully affirmed, but long-term use of estrogen has the risk of increasing endometrial cancer, breast cancer and cardiovascular disease. [0003] Currently, there is no research or patent report of nitrate diet in preventing and treating o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K33/06A61P19/10A61P19/08A61P37/02A61K31/07A61K31/714A61K31/59A61K31/355A61K31/375A61K31/198
CPCA61K33/00A61K33/06A61K31/07A61K31/714A61K31/59A61K31/355A61K31/375A61K31/198A61P19/10A61P19/08A61P37/02A61K2300/00
Inventor 王松灵李文斌王玉记
Owner AIXI BEIJING INT CONSULTING CO LTD
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