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Composition for diagnosis of bone metastasis of cancer and kit comprising same

A technology for bone metastasis and composition, which is applied in the fields of disease diagnosis, biomaterial analysis, measurement devices, etc., can solve problems such as difficult treatment of tumors, and achieve the effect of improving survival rate and advancing diagnosis time.

Pending Publication Date: 2021-02-19
CYTOGEN CORP
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  • Abstract
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Problems solved by technology

[0005] In the past, the diagnosis of bone metastases of cancer using imaging examinations could only be performed in the clinical stage of bone metastases. At this time, the tumor has already spread and it is difficult to carry out effective treatment. Moreover, there are cases where the diagnosis can only be made after morphological changes in bone tissue. limits

Method used

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  • Composition for diagnosis of bone metastasis of cancer and kit comprising same
  • Composition for diagnosis of bone metastasis of cancer and kit comprising same
  • Composition for diagnosis of bone metastasis of cancer and kit comprising same

Examples

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Embodiment

[0094] 1. Obtain peripheral blood monospheres and analyze milk cells

[0095] (1) Experimental method

[0096] In blood samples from cancer patients, for the analysis of milk cells of circulating osteoblasts, samples obtained by liquid biopsy and peripheral blood monospheres were obtained from the corresponding samples. 4 ㏄ of blood samples collected from patients to be diagnosed were placed in heparin tubes containing Ficoll (Pharmacia), and center separation was performed at 1800 rpm for 20 minutes at a temperature of 4°C, thereby inducing Blood layers separated by plasma, monosphere, ficoll, red blood cell (RBC) layers. At this time, only the interface layer (second layer) between the separated plasma and ficoll, that is, the monosphere layer, was carefully separated and transferred to a new tube. Then, after adding PBS solution and washing the monosphere cells, the center separation was performed again at 2000 rpm for 5 minutes at a temperature of 4° C., and only the cle...

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Abstract

A composition and a kit of the present invention can detect osteocalcin and N-cadherin, which are biomarkers separated from circulating osteoblasts in the bone micrometastasis stage of cancer and, assuch, can diagnose metastatic bone cancer at the early stage. In addition, an improvement can be increased in the survival rate of patients with metastatic bone cancer through a method for providing information on the early diagnosis of bone metastasis of cancer according to the present invention.

Description

technical field [0001] The invention relates to a composition for diagnosing cancer bone metastasis and a kit comprising it. Background technique [0002] Bone metastases are malignant tumors that destroy bone tissue. No matter what kind of cancer is diagnosed, the prognosis often deteriorates rapidly. The biggest reason for its formation is that the imaging examination period used in the diagnosis of bone metastases is very long. In breast cancer that often metastasizes to bone, hormone suppression therapy is usually performed for 5 years after the end of primary treatment for prevention and early diagnosis, and "bone scan" is taken repeatedly at intervals of 6-12 months. However, even when the bone scan is diagnosed without symptoms such as pain, fracture, or nerve compression, most of the bone destruction has already occurred, so the response to treatment is poor. [0003] Generally speaking, cancer with bone metastases can be divided into dormant stage, fine bone metas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57407G01N2333/51G01N33/6887G01N33/57415G01N33/57484G01N2800/50G01N2800/56
Inventor 赵珗煜
Owner CYTOGEN CORP
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