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Application of lalang grass rhizome ethyl acetate part extract in preparation of medicine for relaxing pre-contracted tracheal smooth muscles

A technology of ethyl acetate part and tracheal smooth muscle, which is applied in the field of medicine and can solve the problems such as rhizoma Imperatae

Pending Publication Date: 2021-02-09
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no research report on the effect of Imperata rhizome on airway smooth muscle and the treatment of asthma.

Method used

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  • Application of lalang grass rhizome ethyl acetate part extract in preparation of medicine for relaxing pre-contracted tracheal smooth muscles
  • Application of lalang grass rhizome ethyl acetate part extract in preparation of medicine for relaxing pre-contracted tracheal smooth muscles

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Embodiment Construction

[0015] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, and the content of the present invention is not limited to the following embodiments.

[0016] 1. Preparation of the extract of the ethyl acetate part of Rhizoma Imperatae:

[0017] Imperatae (Beijing Tongrentang Pharmacy) crushed Imperatae root, weighed 1000g of Imperatae rhizome powder, soaked in 80% ethanol solution at room temperature for 5 days, and the solid-to-liquid ratio was 1:16. Filtrate was obtained by filtration, and the filtrate was rotary evaporated to obtain ethanol extract. The extract was extracted sequentially with petroleum ether, ethyl acetate, to obtain the corresponding extract. The target phase was concentrated by rotary evaporation to obtain an extract, that is, the ethyl acetate part extract of Rhizoma Imperatae, which was stored in a vacuum drying oven for future use. During the experiment, the ethyl acetate part extract of ...

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Abstract

The invention relates to the technical field of medicines, and in particular relates to application of a lalang grass rhizome ethyl acetate part extract in preparation of a medicine for relaxing pre-contracted tracheal smooth muscles. By detecting the tension of the isolated tracheal ring muscle of an experimental mouse, it is found that the lalang grass rhizome ethyl acetate part extract has theeffect of efficiently relaxing abnormally contracted tracheal smooth muscles; and it is indicated that the lalang grass rhizome ethyl acetate part extract is expected to be applied to relieving asthma. A basis is provided for developing the application of the lalang grass rhizome ethyl acetate part extract in preparation of the medicine for relaxing the pre-contracted tracheal smooth muscles.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of the extract of ethyl acetate part of Rhizoma Imperatae in preparing medicine for relaxing and pre-contracting tracheal smooth muscle. Background technique [0002] Bronchial asthma, referred to as asthma for short, is a chronic airway disease characterized by reversible bronchoconstriction, mucus hyperplasia, and airway hyperresponsiveness. The pathogenesis of asthma is very complex and varies from person to person, such as ion channel lesions, immune system disorders, genetic abnormalities, inflammatory responses, and changes in respiratory structure. Currently, clinically used drugs for the treatment of asthma can be roughly divided into two categories, mainly including symptom-controlling drugs and symptom-relieving drugs. Such as theophylline drugs, leukotriene regulators and β2 receptor agonists. However, long-term use of the above-mentioned drugs will ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P11/06A61P11/08A61K125/00
CPCA61K36/899A61K2236/333A61K2236/35A61P11/06A61P11/08
Inventor 沈金花曾晓月
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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