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Anti-gout composition containing folic acid

A composition and anti-gout technology, applied in the field of medicine, can solve problems such as liver and bone marrow toxicity, few varieties, and poor prevention and treatment of gout, so as to help prevent cardiovascular diseases and increase health status synergistically. Efficacy and prevention of gout attacks

Active Publication Date: 2021-01-19
SHENZHEN AUSA PHARM CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For acute gout, anti-inflammatory drugs are mainly used; in the chronic phase, urate-lowering drugs are mainly used. Commonly used drugs include allopurinol, which can cause liver and bone marrow toxicity and other adverse reactions; non-purine selective xanthine oxidase inhibitor febuxostat ( febuxostat), although current clinical data show that adverse reactions are mostly mild, relevant studies have shown that patients have a higher incidence of cardiovascular events
Although some western medicines for the prevention and treatment of gout have been clinically available to control the symptoms of gout, more clinical data show that due to the limitations of existing medicines, adverse reactions and few varieties of medicines for the treatment of this disease, the choice of medicines is limited, making gout Not getting good prevention and treatment

Method used

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  • Anti-gout composition containing folic acid
  • Anti-gout composition containing folic acid
  • Anti-gout composition containing folic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the tablet preparation (1000 pieces quantity) of composition of the present invention

[0025] formula:

[0026]

[0027] Preparation method: take povidone K30 and prepare an adhesive with 50% ethanol solution, then add celery seed extract into the adhesive, stir evenly, and set aside. Separately take 5-methyltetrahydrofolate, sucralose and pregelatinized starch, mix and sieve, then add milk essence, sodium starch glycolate and dextrin, add the prepared adhesive containing celery seed extract Prepare soft material, granulate with 24 mesh sieve, dry at 55°C for 2 hours, granulate with 24 mesh sieve, add magnesium stearate to mix, and press into tablets. The coating premix is ​​formulated into a solution, and the plain tablet is coated to obtain the tablet of the composition of the present invention.

Embodiment 2

[0028] Embodiment 2: the tablet preparation (1000 pieces quantity) of composition of the present invention

[0029] formula:

[0030]

[0031]

[0032] Preparation method: take povidone K30 and prepare an adhesive with 50% ethanol solution, then add celery seed extract into the adhesive, stir evenly, and set aside. Separately take folic acid, sucralose and pregelatinized starch, mix and sieve, then add milk essence, carboxymethyl starch sodium, dextrin and mix, add the prepared soft material containing celery seed extract binder, 24 mesh Sieve and granulate, dry at 55°C for 2 hours, sieve and granulate with 24 mesh, add magnesium stearate to mix, and press into tablets. The coating premix is ​​formulated into a solution, and the plain tablet is coated to obtain the tablet of the composition of the present invention.

Embodiment 3

[0033] Embodiment 3: the hard capsule preparation (1000 grain amount) of composition of the present invention

[0034] formula:

[0035]

[0036] Preparation method: mix folic acid with 20% microcrystalline cellulose, sieve, add celery seed extract and mix, mix the obtained raw material mixture with the remaining amount of microcrystalline cellulose in an equal amount, and then add lactose and stearin Magnesium acid mixed, then filled with a full-automatic capsule filling machine, and polished to obtain the hard capsule of the composition of the present invention. 1-4 capsules per day.

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PUM

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Abstract

The invention discloses a composition with an anti-gout effect. The composition consists of 100-1500 mg of a celery seed extract, 20-1000 [mu] g of folic acid components and a proper amount of auxiliary materials. The composition has the effect of preventing, relieving or treating gout for gout patients, and all the components have the function synergistic effect.

Description

technical field [0001] The invention relates to a composition, more precisely, the invention relates to a composition product suitable for gout patients to prevent, alleviate or treat gout. The invention belongs to the field of medicine. Background technique [0002] Gout is a crystal-associated arthropathy caused by monosodium urate deposition, which is directly related to hyperuricemia caused by purine metabolic disorders or decreased uric acid excretion. Gout specifically refers to acute gouty arthritis and chronic tophi diseases, often accompanied by hyperlipidemia, hypertension, diabetes, arteriosclerosis and coronary heart disease. At present, the incidence of gout is increasing year by year all over the world, and currently there are few effective drugs with few adverse reactions. According to the National Health and Nutrition Survey (NHANES), the prevalence of gout in the United States increased from 2.64% in 1988-1994 to 3.76% in 2007-2010. A big data based on th...

Claims

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Application Information

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IPC IPC(8): A61K36/23A61K31/519A61P19/06
CPCA61K36/23A61K31/519A61P19/06A61K2300/00
Inventor 白洁黄晓杰于多邢厚恂王滨燕
Owner SHENZHEN AUSA PHARM CO LTD
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