A kind of medical rubber and its preparation method and application

A technology of rubber and rubber stoppers, applied in the field of polymers, can solve the problems of low content of oligomers, difficulties, etc., and achieve the effect of solving poor compatibility and improving safety

Active Publication Date: 2022-07-08
NOVASHIN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem of low-molecular-weight compounds caused by vulcanizing agents can be solved by optimizing processes such as sulfur-free vulcanization and zinc-free vulcanization, but using existing technologies to produce butyl rubber with low oligomer content and its halogenated Butyl rubber is difficult

Method used

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  • A kind of medical rubber and its preparation method and application
  • A kind of medical rubber and its preparation method and application
  • A kind of medical rubber and its preparation method and application

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preparation example Construction

[0084] Exemplarily, the preparation method includes the steps of: at least one isoolefin monomer and at least one conjugated diene monomer, and a slurry polymerization reaction occurs in the polar solvent under the action of a Lewis acid and an initiator ; Or, the polymerization reaction product is reacted with chlorine or liquid bromine.

[0085] R in the initiator R-X is a polyisobutenyl group, and R has the structure shown in formula (2):

[0086]

[0087] Wherein, k≥4, such as k≥5, another example k≥10, another example k≥20, exemplarily, k=4, 5, 6, 7, 8, 9, 10, 13, 17, 19 or 22 ; X is Cl.

[0088] Exemplarily, the medical rubber is butyl rubber or chlorinated butyl rubber, and the butyl rubber is prepared by a method comprising the following steps: isobutylene monomer and isoprene monomer, in Lewis acid and initiator react in a solvent under the action;

[0089] The chlorinated butyl rubber is prepared by a method comprising the following steps: isobutylene monomer a...

Embodiment 1

[0100] Butyl rubber, which is a medical rubber, is prepared from isobutylene monomer and isoprene monomer by cationic polymerization. Its number average molecular weight is between 50,000 and 200,000, and its molecular weight distribution index is between 1.5 and 4.0.

[0101] The butyl rubber is used to prepare medical rubber stoppers, and the method for improving the compatibility between medicines and butyl rubber in medical rubber stoppers, wherein the butyl rubber is prepared by the following steps:

[0102] In an anhydrous and oxygen-free glove box, add monochloromethane to a glass reactor with mechanical stirring, cool it to -95 ° C, add isobutylene monomer and isoprene monomer, the concentration of isobutylene is 10wt%, isoprene The concentration is 0.28 wt%. After stirring, the mixture of Lewis acid and initiator is added, and the catalytic reaction proceeds to obtain butyl rubber. The additions and proportions of Lewis acid and initiator are shown in Table 1.

[0...

Embodiment 2-6

[0108] In an anhydrous and oxygen-free glove box, the mixed solvent of isopentane and ethyl chloride (weight ratio of isopentane / ethyl chloride = 3:1) was added to a glass reactor with mechanical stirring, cooled to -80 °C, and isobutylene was added. Monomer and isoprene monomer, the concentration of isobutene was 10 wt% and the concentration of isoprene was 0.28 wt%. After stirring, the mixture of Lewis acid and initiator is added, and the catalytic reaction proceeds to obtain butyl rubber. The additions and proportions of Lewis acid and initiator are shown in Table 2. Initiators R-X were prepared from isobutylene polymer and HCl according to methods known in the art.

[0109] Table 2.

[0110] Example Initiator * (ppm)

[0111] Note*: RCl refers to the structural formula such as formula (2), Mn and PDI refer to the molecular weight of R, and RCl molecular weight distribution coefficient (Mw / Mn).

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Abstract

The invention discloses a medical rubber and a preparation method and application thereof. The rubber includes at least one isoolefin polymer and / or a halogenated isoolefin polymer; wherein the polymerized monomers of the isoolefin polymer include at least one isoolefin monomer, and optionally at least one conjugated A diene monomer, the polymerized monomer is prepared by cationic polymerization to obtain the isoolefin polymer; the halogenated isoolefin polymer is obtained by halogenating the isoolefin polymer. Based on the total weight of the isoolefin polymer, the weight content of the oligomer in the isoolefin polymer is less than or equal to 0.1%; the oligomer is an oligomer with a carbon number of ≤21. The oligomer content in the obtained medical rubber is very low, especially the medical rubber stopper prepared from the medical rubber can greatly reduce the content of oligomers migrated to the surface of the rubber stopper or extracted by the drug, which effectively solves the problem. The problem of poor compatibility between medicines and rubber stoppers is solved, and the safety of use is improved.

Description

technical field [0001] The invention belongs to the field of macromolecules, relates to isoolefin cationic polymerization, and in particular relates to a medical rubber containing an isoolefin polymer, a preparation method and application thereof. Background technique [0002] Industrially, isoolefin polymers are prepared by carbocationic polymerization processes. Among them, the important varieties are polyisobutylene, butyl rubber, etc. Butyl rubber has good chemical stability and thermal stability, the most prominent advantage is good air tightness and water tightness, and is widely used in the manufacture of inner tubes, anti-vibration Rubber, industrial rubber sheets, medical rubber, etc. In terms of medical rubber, butyl rubber and its downstream products, halogenated butyl rubber, have gradually replaced natural rubber for the preparation of medical rubber plugs due to their excellent properties. [0003] The mechanism of carbocationic polymerization of isoolefins an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F210/12C08F210/14C08F236/08C08F214/06C08F8/20C08F4/54
CPCC08F210/12C08F210/14C08F8/20C08F236/08C08F214/06C08F4/54
Inventor 汪帆朱荣欣杨建春
Owner NOVASHIN CO LTD
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