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Application of perilla leaf extract to preparation of medicament for treating chronic obstructive pulmonary diseases (COPD)

A technology of perilla leaf extract and chronic obstructive pulmonary disease, which is applied in the field of perilla leaf extract to achieve the effect of simple preparation process, low toxic and side effects, and prevention and treatment of chronic obstructive pulmonary disease

Active Publication Date: 2020-12-15
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no relevant research reports on perilla leaf extract and its treatment of COPD airway inflammation. In order to effectively explain the role of traditional Chinese medicine in the treatment of COPD, and to provide theoretical basis and practical experience for finding more active anti-COPD drugs, we prepared perilla leaf extract and its anti-COPD activity was evaluated

Method used

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  • Application of perilla leaf extract to preparation of medicament for treating chronic obstructive pulmonary diseases (COPD)
  • Application of perilla leaf extract to preparation of medicament for treating chronic obstructive pulmonary diseases (COPD)
  • Application of perilla leaf extract to preparation of medicament for treating chronic obstructive pulmonary diseases (COPD)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: the preparation of perilla leaf extract

[0042] Take 1.5 kg of dried perilla leaves, add 5 liters of 70% ethanol, heat to reflux for 1.5 hours, and filter while hot. The filter residue was treated once more in the same way; the filtrates were combined twice, and the ethanol was recovered under reduced pressure to obtain 65 g of extract. The extract was added with 300mL of water and stirred to form a suspension, which was extracted twice with 150mL of ethyl acetate respectively. The remaining water was dissolved by adding 1580 mL of 95% ethanol, precipitated at room temperature for 24 hours, filtered under reduced pressure, and the filter residue was dissolved in 50 mL of water, freeze-dried and crushed to obtain perilla leaf extract.

Embodiment 2

[0043] Embodiment 2: dosage form preparation

[0044] Capsules: Perilla leaf extract 100g, add dextrin 147.5g, magnesium stearate 2.5g, mix well, make 1000 capsules according to capsule preparation method, fill in 250mg capsules, each capsule contains perilla leaf extract 100mg , and its total amount is not less than 50%.

[0045] Tablets: Take 100g of perilla leaf extract, add 100g of starch, 80g of dextrin, and 15g of sucrose, stir well, make granules, dry below 60°C, add appropriate amount of magnesium stearate and talc, mix well, Compressed into 1000 tablets, coated with sugar or film, that is.

[0046] Granules: Take 100g of perilla leaf extract, add appropriate amount of sucrose and dextrin, make granules according to the granule preparation method, and dry to make 1000g.

[0047] Oral solution: Take perilla leaves, heat and reflux with 70% ethanol for 1.5 hours to extract twice, filter, combine the filtrate, recover ethanol under reduced pressure; add the same amount ...

experiment example 1

[0049] Experimental example 1: Inhibitory effect of perilla leaf extract on airway inflammation induced by cigarettes in COPD mice

[0050] Methods: SPF grade male BALB / c mice, 18-20g, were randomly divided into normal control group, model control group, positive control group (roflumilast, 2mg / kg, intragastric administration), drug treatment group (purple Perilla leaf extract 50, 100mg / kg, intragastric administration), 20 rats in each group. Except for the blank control group, on the first day and the 12th day of the experiment, the animals in each group were instilled with 50 μl of normal saline solution containing 40 μg LPS into the trachea after anesthesia; Place in the small animal smoke inhalation microenvironment preparation system (cigarette smoke: 260-300ppm, temperature 22-28°C, oxygen ≥ 18.0%) for fumigation, 4 cigarettes each time, 60min / time, once a day, continuously For 3 weeks, it was given by intragastric administration 1 hour before smoking every day. One ho...

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Abstract

The invention discloses application of a perilla leaf extract to preparation of a medicament for treating the chronic obstructive pulmonary disease (COPD). The perilla leaf extract disclosed by the invention has a reversing effect on the cigarette-induced COPD model mouse lung inflammation pathological injury; generation of inflammatory cytokines of TNF-alpha and IL-1beta in the Bronchoalveolar Lavage Fluid (BALF) of a model mouse can be obviously inhibited; and the total number of leukocytes and the recruitment of lymphocytes and eosinophilic granulocyte in the BALF of the model mouse are obviously inhibited.

Description

technical field [0001] The invention relates to a perilla leaf extract, its preparation method and its application in the preparation of medicine or food for preventing and / or treating chronic obstructive pulmonary disease, belonging to the technical field of medicine or food. Background technique [0002] The prevalence and mortality of chronic obstructive pulmonary disease (COPD) worldwide are increasing year by year, and it has become a chronic disease that seriously threatens public health. Epidemiological studies have shown that the current global incidence of COPD among people over 40 years old is about 9-10%, the average incidence rate of American adults is 6.2%, while the average incidence rate in my country is as high as 8.2%, which has seriously endangered human health and caused heavy economic and social burden. COPD is a disease characterized by airway limitation. Airflow limitation is not completely reversible and develops progressively. It mainly involves the l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/535A61P11/00A61K127/00
CPCA61K36/535A61P11/00A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53Y02A50/30
Inventor 林明宝姚春所侯琦张梓倩白金叶马培吉腾飞杨慧袁继巧李姝仪
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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