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Composition for preventing, alleviating, or treating cachexia and muscle loss

A technology for muscle loss and composition, applied in the field of peony root extract, can solve the problems of reducing the response rate of anti-cancer treatment, difficult to achieve anti-cancer treatment, reducing the quality of life of patients, etc., so as to reduce or treat cachexia and muscle loss, reduce Loss of appetite, weight loss effects

Active Publication Date: 2020-12-04
CHUNG ANG UNIV IND ACADEMIC COOP FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cachexia and muscle loss, which occur at high frequency in cancer patients, reduce the response rate to anticancer therapy, make it difficult to achieve effective anticancer therapy, and reduce the quality of life of patients

Method used

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  • Composition for preventing, alleviating, or treating cachexia and muscle loss
  • Composition for preventing, alleviating, or treating cachexia and muscle loss
  • Composition for preventing, alleviating, or treating cachexia and muscle loss

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1. Preparation of Radix Paeoniae Alba Extract

[0063] 250 g of peony roots and 2 L of 30% ethanol were placed in a 3 L reactor, and extracted under reflux at 65° C. for 4 hours using a reflux extractor. The first extract was filtered, and 2 L of 30% ethanol was added again to the residue, followed by a second extraction under the same conditions. After that, the second extract was filtered and mixed with the first extract, and then the resulting extract was concentrated at 50° C. or lower to remove ethanol. The concentrated extract was freeze-dried and then homogenized with a mixer. As a result of the preparation of the extract, Paeoniae officinalis root extract was obtained with a dry weight of 43 g (17.20% yield).

Embodiment 2

[0064] Example 2. Alleviating effect of Paeoniae officinalis root extract on tumor-induced cachexia and muscle loss

[0065] 2-1. Preparation of experimental animals and experimental methods

[0066]As experimental animals, 4-week-old male C57BL / 6 mice (weight 18 to 20 g) were purchased from Central Lab Animal Inc., allowed to acclimatize in a laboratory animal facility for 1 week, and then used for experiments. During the experiment, animals were allowed access to solid feed and water ad libitum and were housed in cages at a temperature of 22±2°C and a relative humidity of 60±5% under a 12-h light / 12-h dark cycle.

[0067] The mice were divided into a normal group (healthy group), a control group (tumor induction group), a conventional drug administration group and a peony root extract administration group, each consisting of 9 animals. Each animal in the normal group was subcutaneously injected with 100 μl of PBS (phosphate buffered saline, phosphate-buffered saline), and t...

Embodiment 3

[0098] Example 3. Alleviation of Paeoniae officinalis Root Extract on Cachexia Caused by Anticancer Drugs

[0099] 3-1. Preparation of experimental animals

[0100] As experimental animals, 4-week-old male C57BL / 6 mice (weight 18 to 20 g) were purchased from Central Lab Animal Inc., allowed to acclimatize in a laboratory animal facility for 1 week, and then used for experiments. During the experiments, animals were allowed access to solid feed and water ad libitum and were housed in cages at 22±2°C and 60%±5% relative humidity under a 12h light / 12h dark cycle.

[0101] The mice were divided into a normal group, a control group and a peony root extract-administered group, each consisting of 9 animals. For groups other than the normal (healthy) group, 5-fluorouracil (hereinafter referred to as 5-FU), an anticancer drug commonly used against digestive system cancer, was intraperitoneally administered once at a dose of 200 mg / kg to induce the anticancer drug side effect. Seven ...

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Abstract

The present invention relates to a composition comprising Chinese peony extract as an active ingredient, the composition alleviating loss of appetite, weight loss, muscle loss, and fatigue and inhibiting haematopoietic toxicity, thereby being effectively usable for preventing, alleviating, or treating cachexia and muscle loss.

Description

technical field [0001] The present disclosure relates to a composition for preventing, alleviating or treating cachexia comprising Paeoniae officinalis root extract as an active ingredient Background technique [0002] Cachexia is a syndrome often associated with chronic diseases such as cancer, tuberculosis, AIDS, and chronic obstructive pulmonary disease, and refers to a metabolic disorder of the body characterized by persistent loss of appetite (also called "anorexia") and weight loss catabolic state of the body, resulting in malnutrition, metabolic imbalance, and loss of muscle or fat. Unlike patients with other chronic diseases, cancer patients suffer not only from cachexia but also side effects of various anticancer treatments (Fearon K. et al., Lancet Oncol 2011; 12(5):489-495). [0003] Cachexia occurs in 50% to 80% of patients with gastrointestinal and lung cancers, and mortality due to cachexia reaches 20% to 30%. Cancer cachexia is characterized by muscle loss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/65A23L33/105A61P35/00
CPCA23L33/105A61K36/65A61P21/06A61K31/513A23V2002/00A61K2300/00A23V2200/308A23V2200/316A61P35/00A61K2236/333
Inventor 尹裕植张在雄蔡世娟裵泰贤李贤志宋在源
Owner CHUNG ANG UNIV IND ACADEMIC COOP FOUND
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