Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Misfolded tdp-43 binding molecules

A TDP-43, binding molecule technology, applied in the fields of drug combination, analytical materials, biomaterial analysis, etc., can solve problems such as complex diagnosis

Pending Publication Date: 2020-11-03
AC IMMUNE SA
View PDF69 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diagnosis of these syndromes is complex and conclusive conclusions can only be drawn by immunohistochemistry-based post-mortem tissue analysis to detect aggregated proteins and characterize affected brain regions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Misfolded tdp-43 binding molecules
  • Misfolded tdp-43 binding molecules
  • Misfolded tdp-43 binding molecules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0250] X. Definition

[0251] An "antigen binding molecule" as used herein is any molecule that can specifically or selectively bind to an antigen. A binding molecule may comprise or be an antibody or fragment thereof. Anti-misfolded TDP-43 binding molecules are molecules that bind misfolded TDP-43 protein at specific recognition sites (epitopes), such as anti-TDP-43 antibodies or fragments thereof. That is, the antigen-binding molecule of the present invention binds to an epitope in the amino acid sequence of SEQ ID NO: 1, preferably at amino acid positions 215 to 222 thereof. Other misfolding-resistant TDP-43 binding molecules can also include multivalent molecules, multispecific molecules (for example, diabodies (diabodies)), fusion molecules, aptamers, affimers (avimers) or other naturally occurring or recombinantly produced molecules. Exemplary antigen-binding molecules useful in the invention include antibody-like molecules. Antibody-like molecules are molecules that...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention is in the field of transactive response DNA binding protein with a molecular weight of 43 kDa (TARDB or also TDP-43). The invention relates to TDP-43 specific binding molecules,in particular to anti-TDP-43 antibodies or an antigen-binding fragment or a derivative thereof and uses thereof. The present invention provides means and methods to diagnose, prevent, alleviate and / ortreat a disorder and / or abnormality associated with misfolded TDP-43 including but not limited to frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD, sporadicand familial), and / or Parkinson's disease (PD). The present invention provides modified conformation-specific antigenic peptides and peptide fragments derived from the TDP-43 protein and the antibodies obtainable by said peptides or fragments for use in the diagnosis, prevention, alleviation and / or treatment of TDP-43-related disorders and / or abnormalities.

Description

technical field [0001] The present invention is in the field of transactivation responsive DNA binding protein (TARDB or also known as TDP-43) having a molecular weight of 43 kDa. The present invention relates to TDP-43-specific binding molecules, especially anti-TDP-43 antibodies or antigen-binding fragments or derivatives thereof and uses thereof. The present invention provides means and methods for diagnosing, preventing, alleviating and / or treating disorders and / or abnormalities associated with misfolded TDP-43, including but not limited to frontotemporal dementia (FTD) , amyotrophic lateral sclerosis (ALS), Alzheimer's disease (Alzheimer's disease, AD, sporadic and familial) and / or Parkinson's disease (Parkinson's disease, PD). The present invention provides modified conformation-specific antigenic peptides and peptide fragments from TDP-43 protein and antibodies obtainable from said peptides or fragments for use in diagnosis, prevention, alleviation and / or treatment of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07K16/18A61K39/395
CPCA61K39/395C07K16/18C07K2317/92G01N33/6896A61P25/28A61K2039/505A61K47/6843A61K47/6803A61K45/06C07K2317/34G01N2800/28
Inventor 塔玛拉·谢雷德尼纳奥斯卡·阿道夫松
Owner AC IMMUNE SA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com