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Continuous catalytic hydrogenation equipment and continuous catalytic hydrogenation method for pyridine compounds

A catalytic hydrogenation and pyridine technology, applied in pressure vessels, organic chemistry, sampling devices used in chemical processes, etc., can solve problems such as effective control of difficult catalytic effects, and achieve the effect of optimizing catalytic effects.

Active Publication Date: 2022-06-24
JINLIN ASYMCHEM PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to provide a continuous catalytic hydrogenation equipment and continuous catalytic hydrogenation method for pyridine compounds, so as to solve the problem that the gas-liquid-solid three-phase continuous reaction equipment in the prior art is difficult to effectively realize the catalytic effect in each reactor. problem of control

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  • Continuous catalytic hydrogenation equipment and continuous catalytic hydrogenation method for pyridine compounds

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Experimental program
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Effect test

Embodiment 1

[0039] The structure of continuous catalytic hydrogenation equipment is as follows figure 1 As shown, the 4-stage fixed-bed reactors 30 are used in series, and the materials are fed from the bottom to the top. 200 g of raw material 2-picoline was dissolved in 800 g of methanol for use, and was pumped into the first-stage fixed bed reactor 30 by means of a feed pump. The length-diameter ratio of the fixed-bed reactors 30 at all levels is 80. The fixed-bed reactors 30 are filled with 5 g of spherical rhodium-carbon with a particle size of 3 mm and a loading of 5% as a catalyst. Above and below the catalyst, three spherical particles of 3 mm are laid. Alumina was used as a filler, and nitrogen was used to purge the series-connected fixed-bed reactors 30 for 0.5 h. At the same time, the external bath temperature of the heat-exchange jackets 40 of each fixed-bed The heat exchange medium is heat transfer oil, which is supplied by bottom-in and top-out type. During the heating proc...

Embodiment 2

[0041] The structure of continuous catalytic hydrogenation equipment is as follows figure 1 As shown, the 4-stage fixed-bed reactors 30 are used in series, and the materials are fed from the bottom to the top. 200 g of 2-picoline was dissolved in 800 g of methanol for later use. The length-diameter ratio of the fixed-bed reactors 30 at all levels is 80. The fixed-bed reactors 30 are filled with 5 g of spherical rhodium-carbon with a particle size of 3 mm and a loading of 5% as a catalyst. Above and below the catalyst, three spherical particles of 3 mm are laid. Alumina was used as a filler, and nitrogen was used to purge the series-connected fixed-bed reactors 30 for 0.5 h. At the same time, the external bath temperature of the heat-exchange jackets 40 of each fixed-bed The heat exchange medium is heat transfer oil, which is supplied by bottom-in and top-out type. During the heating process, the fixed bed reactor 30 device was purged with hydrogen. After the heating is comp...

Embodiment 3

[0043] The structure of continuous catalytic hydrogenation equipment is as follows figure 1 As shown, the 4-stage fixed-bed reactors 30 are used in series, and the materials are fed from the bottom to the top. 200 g of 2-picoline was dissolved in 800 g of methanol for later use. The length-diameter ratio of the fixed-bed reactors 30 at all levels is 80. The fixed-bed reactors 30 are filled with 5 g of spherical rhodium-carbon with a particle size of 3 mm and a loading of 5% as a catalyst. Above and below the catalyst, three spherical particles of 3 mm are laid. Alumina was used as a filler, and nitrogen was used to purge the series-connected fixed-bed reactors 30 for 0.5 h. At the same time, the external bath temperature of the heat-exchange jackets 40 of each fixed-bed The heat exchange medium is heat transfer oil, which is supplied by bottom-in and top-out type. During the heating process, the fixed bed reactor 30 device was purged with hydrogen. After the heating is comp...

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Abstract

The invention provides a continuous catalytic hydrogenation device and a continuous catalytic hydrogenation method for pyridine compounds. Continuous catalytic hydrogenation equipment, including: a liquid raw material supply unit; a hydrogen supply unit; at least three fixed-bed reactors connected in series, each fixed-bed reactor has a feed inlet at the bottom and a product outlet at the top, and a liquid raw material supply unit The hydrogen supply unit is connected to the feed port of the first-stage fixed-bed reactor. Each fixed-bed reactor has a partition inside, and the partition is used to support catalyst and filler. On the connecting pipeline between the fixed-bed reactors of each stage Sampling ports are provided; heat exchange jackets are provided one-to-one with the fixed-bed reactor, and each heat-exchange jacket is set on the outer wall of the fixed-bed reactor in one-to-one correspondence; The product outlet connection of the fixed bed reactor is set. The equipment of the present application facilitates the loading and replacement of catalysts in each fixed-bed reactor and effectively controls the catalytic effect.

Description

technical field [0001] The invention relates to the technical field of catalytic hydrogenation of pyridine compounds, in particular to a continuous catalytic hydrogenation device and a continuous catalytic hydrogenation method for pyridine compounds. Background technique [0002] Piperidine and its derivatives are a class of heterocyclic compounds with a wide range of physiological and pharmacological activities, which have high research value and application prospects in anti-cancer, anti-inflammatory, sedative, hypnotic, etc. It has a wide range of applications in organic synthesis. Piperidine and its derivatives are usually prepared from the corresponding pyridine and its derivatives by catalytic hydrogenation. This synthesis method has high reaction yield and simple product post-processing, and has been widely used in industry. [0003] The industrial production of catalytic hydrogenation reduction reaction mainly uses the high pressure reactor as the reaction vessel. B...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J3/04C07D211/12G01N1/10
CPCB01J3/04C07D211/12G01N1/10
Inventor 洪浩卢江平丰惜春孙兴芳
Owner JINLIN ASYMCHEM PHARM CO LTD
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