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Continuous catalytic hydrogenation equipment and continuous catalytic hydrogenation method for pyridine compounds

A catalytic hydrogenation and pyridine-based technology, applied in pressure vessels used in chemical processes, organic chemistry, sampling devices, etc., can solve problems such as effective control of difficult catalytic effects

Active Publication Date: 2020-10-27
JINLIN ASYMCHEM PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The main purpose of the present invention is to provide a continuous catalytic hydrogenation equipment and continuous catalytic hydrogenation method for pyridine compounds, so as to solve the problem that the gas-liquid-solid three-phase continuous reaction equipment in the prior art is difficult to effectively realize the catalytic effect in each reactor. problem of control

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  • Continuous catalytic hydrogenation equipment and continuous catalytic hydrogenation method for pyridine compounds

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Experimental program
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Effect test

Embodiment 1

[0039] The structure of continuous catalytic hydrogenation equipment is as follows: figure 1 As shown, the 4-stage fixed-bed reactors 30 are used in series, and the materials are fed in from the bottom to the top. Dissolve 200 g of the raw material 2-picoline in 800 g of methanol for use and pump it into the first-stage fixed-bed reactor 30 using a feed pump. The length-to-diameter ratio of the fixed-bed reactors 30 at all levels is 80, and in the fixed-bed reactors 30, the spherical rhodium-charcoal 5g of the 5% loading capacity of packing particle diameter is 3mm as catalyzer, lays 3mm spherical particles three above and below the catalyzer Al2O3 is used as a filler, and nitrogen gas is used to purge the fixed-bed reactors 30 in series for 0.5 h. The heat exchange medium is heat transfer oil, which is fed from bottom to top. During the heating process, the fixed bed reactor 30 device was purged with hydrogen. After the temperature rise is completed, the outlet valve is ad...

Embodiment 2

[0041] The structure of continuous catalytic hydrogenation equipment is as follows: figure 1 As shown, the 4-stage fixed-bed reactors 30 are used in series, and the materials are fed in from the bottom to the top. Dissolve 200 g of 2-picoline in 800 g of methanol for use. The length-to-diameter ratio of the fixed-bed reactors 30 at all levels is 80, and in the fixed-bed reactors 30, the spherical rhodium-charcoal 5g of the 5% loading capacity of packing particle diameter is 3mm as catalyzer, lays 3mm spherical particles three above and below the catalyzer Al2O3 is used as a filler, and nitrogen gas is used to purge the fixed-bed reactors 30 in series for 0.5 h. The heat exchange medium is heat transfer oil, which is fed from bottom to top. During the heating process, the fixed bed reactor 30 device was purged with hydrogen. After the temperature rise is completed, adjust the outlet valve to adjust the pressure of the series fixed bed reactor 30 to 7-8 MPa, and at the same t...

Embodiment 3

[0043] The structure of continuous catalytic hydrogenation equipment is as follows: figure 1 As shown, the 4-stage fixed-bed reactors 30 are used in series, and the materials are fed in from the bottom to the top. Dissolve 200 g of 2-picoline in 800 g of methanol for use. The length-to-diameter ratio of the fixed-bed reactors 30 at all levels is 80, and in the fixed-bed reactors 30, the spherical rhodium-charcoal 5g of the 5% loading capacity of packing particle diameter is 3mm as catalyzer, lays 3mm spherical particles three above and below the catalyzer Al2O3 is used as a filler, and nitrogen gas is used to purge the fixed-bed reactors 30 in series for 0.5 h. The heat exchange medium is heat transfer oil, which is fed from bottom to top. During the heating process, the fixed bed reactor 30 device was purged with hydrogen. After the temperature rise is completed, adjust the outlet valve to adjust the pressure of the series fixed bed reactor 30 to 4-5 MPa, and at the same t...

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Abstract

The invention provides continuous catalytic hydrogenation equipment and a continuous catalytic hydrogenation method for pyridine compounds. The continuous catalytic hydrogenation equipment comprises:a liquid raw material supply unit; a hydrogen supply unit; at least three stages of fixed bed reactors sequentially connected in series, wherein each fixed bed reactor is provided with a feeding holein the bottom and a product outlet in the top, the liquid raw material supply unit and the hydrogen supply unit are connected with a feeding hole of the first-stage fixed bed reactor, a partition plate is arranged in each fixed bed reactor and is used for bearing a catalyst and filler, and a sampling hole is formed in a connecting pipeline between all the stages of fixed bed reactors; heat exchange jackets, which are in one-to-one correspondence with the fixed bed reactors, and are sleeved to the outer walls of the fixed bed reactors in a one-to-one correspondence manner; and a gas-liquid separator, which is connected with a product outlet of the last-stage fixed bed reactor. The equipment disclosed by the invention is beneficial to filling and replacing the catalyst of each fixed bed reactor, and the catalytic effect is effectively controlled.

Description

technical field [0001] The invention relates to the technical field of catalytic hydrogenation of pyridine compounds, in particular to a continuous catalytic hydrogenation equipment and continuous catalytic hydrogenation method of pyridine compounds. Background technique [0002] Piperidine and its derivatives are a class of heterocyclic compounds with a wide range of physiological and pharmacological activities. They have high research value and application prospects in anticancer, anti-inflammatory, sedative, and hypnotic aspects. In addition, they can also be used as chiral reagents in It is widely used in organic synthesis. Piperidine and its derivatives are usually prepared by catalytic hydrogenation of the corresponding pyridine and its derivatives. This synthetic method has high reaction yield and simple post-treatment of the product, and has been widely used in industry. [0003] The industrial production of catalytic hydrogenation reduction reaction mainly uses hig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J3/04C07D211/12G01N1/10
CPCB01J3/04C07D211/12G01N1/10
Inventor 洪浩卢江平丰惜春孙兴芳
Owner JINLIN ASYMCHEM PHARM CO LTD
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