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Application of umbilical cord mesenchymal stem cells in preparation of medicine for inhibiting inflammatory factors

A technology of stem cells and inflammatory factors, applied in the field of rheumatology immunology, can solve the problems of immune tolerance disorder, damaged joint tissue cell repair, immune effect disorder, etc.

Inactive Publication Date: 2020-10-23
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

RA is an inflammatory autoimmune disease involving multiple systems, and its pathogenesis is mainly the disorder of immune effects. It is difficult to solve the problems of RA immune tolerance disorder and the repair of damaged joint tissue cells with rheumatism guideline medication

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  • Application of umbilical cord mesenchymal stem cells in preparation of medicine for inhibiting inflammatory factors

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Embodiment Construction

[0012] The implementation of the present invention will be described in detail below with examples, so as to fully understand and implement the implementation process of how the present invention uses technical means to solve technical problems and achieve technical effects.

[0013] The invention provides the application of umbilical cord-mesenchymal stem cells (Umbilical cord-mesenchymal stem cells, UC-MSC) in the preparation of medicines for treating rheumatoid arthritis. academic characteristics.

[0014] With the development of stem cell regenerative medicine, research on stem cells continues to deepen, and the application of stem cells in the treatment of immune diseases has become a hot spot. Among them, mesenchymal stem cells (MSCs) are a type of pluripotent stem cells derived from the mesoderm and ectoderm in the early development, and were originally found in the bone marrow. It has the biological characteristics of regeneration and repair of parenchymal tissues and...

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Abstract

The invention discloses application of umbilical cord mesenchymal stem cells in preparation of a medicine for inhibiting inflammatory factors IL-6 and TNF-alpha. The umbilical cord mesenchymal stem cells are derived from human umbilical cords of full-term pregnancy. The umbilical cord mesenchymal stem cells UC-MSC can obviously reduce the levels of TNF-alpha and IL-6 in serum, and solve the fundamental problems of repairing diseased cells, restoring cell tissue functions and improving immune disorder for RA patients.

Description

technical field [0001] The invention belongs to the technical field of rheumatic immunology treatment, and in particular relates to the application of umbilical cord mesenchymal stem cells in the preparation of drugs for inhibiting inflammatory factors. Background technique [0002] Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease with erosive symmetric polyarthritis as the main clinical manifestation and a high disability rate. The disease is distributed globally and is one of the main causes of human loss of labor force and disability. The prevalence of RA in my country is about 0.32%-0.36%. It can occur at any age, 80% of the cases are between 35 and 50 years old, and the number of female patients is about 3 times that of males. The clinical manifestations are symmetrical and persistent polyarthritis mainly involving small joints such as hands and wrists. The basic pathological changes of RA are synovitis and vasculitis. Synovitis is the basis of joi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61P29/00A61P19/02
CPCA61K35/28A61P29/00A61P19/02
Inventor 王黎明李世梅
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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