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Application of benserazide and composition of benserazide and fluconazole in preparation of antifungal products

A benserazide and antifungal technology, applied in the field of preparation of antifungal products, to achieve the effect of improving economic value, enhancing antifungal effect, and overcoming the problem of fungal drug resistance

Active Publication Date: 2020-09-25
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Azoles are currently the main antifungal drugs used clinically. Among them, fluconazole is safe, effective and inexpensive, and is widely used clinically. However, the continuous emergence of drug resistance makes it urgent to find new antifungal means

Method used

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  • Application of benserazide and composition of benserazide and fluconazole in preparation of antifungal products
  • Application of benserazide and composition of benserazide and fluconazole in preparation of antifungal products
  • Application of benserazide and composition of benserazide and fluconazole in preparation of antifungal products

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Experimental program
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Embodiment 1

[0056] 1. Materials

[0057] 1.1 Drugs and reagents

[0058] Fluconazole (FLC), Dalian Meilun Biotechnology Co., Ltd.;

[0059] Benserazide (Benserazide, BEH), Dalian Meilun Biotechnology Co., Ltd.;

[0060] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0061] TTC-Sa Paul medium, Qingdao Hi-tech Park Haibo Biotechnology Co., Ltd.;

[0062] Yeast paste, Beijing Aoboxing Biotechnology Co., Ltd.;

[0063] Peptone, Beijing Aoboxing Biotechnology Co., Ltd.;

[0064] Glucose, Beijing Dingguochangsheng Biotechnology Co., Ltd.;

[0065] Agar powder, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0066] PBS phosphate buffer, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0067] Sodium hydroxide, state-owned Shandong Shanxian Organic Chemical Factory, batch number 940420;

[0068] Potassium dihydrogen phosphate, Shanghai Xinbao Fine Chemical Factory, batch number 200602132;

[0069] RPMI 1640 API powder, American GIBCO c...

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Abstract

The invention particularly relates to application of benserazide and a composition of the benserazide and fluconazole in preparation of antifungal products. In recent years, the fungal infection rateand the death rate caused by the fungal infection rate are in a rising trend, wherein candida threatens the human body most seriously. At present, azole drugs are first-line drugs for antifungal treatment, but the treatment effect is not ideal due to continuous appearance of drug-resistant bacteria. Aiming at the current situation, the invention provides an antifungal effect of the benserazide, and compound entities with the antifungal effect are enriched. Furthermore, research of the invention also shows that the benserazide can cooperate with the fluconazole, and has a good inhibition effecton candida with large harm such as candida albicans, candida krusei and candida glabrata, the drug sensitivity of drug-resistant strains is improved, and the drug dosage is reduced.

Description

technical field [0001] The invention belongs to the technical field of antifungal drugs, and in particular relates to the application of benserazide and a pharmaceutical composition composed of benserazide and fluconazole in the preparation of antifungal products. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] In recent years, due to the use of broad-spectrum antibiotics, the development of techniques such as organ transplantation and indwelling catheters, and the increase in cancer radiotherapy and chemotherapy, the number of immunocompromised patients has continued to increase, and the rate of deep fungal infections has increased significantly. Despite the treatment of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61K45/06A61K31/4196A61P31/10
CPCA61K31/165A61K31/4196A61K45/06A61P31/10A61K2300/00
Inventor 孙淑娟陈雪琪鲁春燕闫海英任洪耀
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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