Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Bispecific nanomicelles based on folic acid targeting and Cherenkov radiation response and their preparation methods and applications

A nano-micelle and bispecific technology, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems of lack of tumor cell specificity, limited effective delivery, and bioavailability Low-level problems, to achieve the effect of reducing non-specific enrichment, enhancing specificity, and overcoming the limitation of penetration depth

Active Publication Date: 2021-07-13
XI AN JIAOTONG UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Doxorubicin (DOX) is a widely used chemotherapeutic agent for many different types of cancer, but overuse of DOX can cause significant cardiotoxicity
Commonly used chemotherapy drugs such as doxorubicin (DOX), paclitaxel, and cisplatin all have strong hydrophobicity, which limits their effective delivery in vivo and low bioavailability
In addition, due to the lack of specificity for tumor cells, simple intraperitoneal or intravenous injection of chemotherapy drugs will cause strong toxic side effects in the body

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bispecific nanomicelles based on folic acid targeting and Cherenkov radiation response and their preparation methods and applications
  • Bispecific nanomicelles based on folic acid targeting and Cherenkov radiation response and their preparation methods and applications
  • Bispecific nanomicelles based on folic acid targeting and Cherenkov radiation response and their preparation methods and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0038] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0039] It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a bispecific nanomicelle based on folic acid targeting and Cherenkov radiation response, a preparation method and application thereof, and belongs to the technical field of nanomaterial manufacturing and application. The present invention prepares DOX derivatives (increased hydrophobicity) by coupling hexadecyl groups with a photosensitive group nitrobenzyl and embedding them in folic acid-modified amphiphilic polymers (FA‑PEG‑PCL). Nanomicelle NM / DOC, NM / DOC can use folic acid to target tumor cells, and further in the process of X-ray local radiotherapy, the photosensitive group-nitrobenzyl group is broken by the generated Cherenkov radiation, increasing The hydrophilicity of DOX triggers drug release, organically integrates radiotherapy and chemotherapy, and enhances the specificity of chemotherapy drug action through the active targeting and responsive drug release of NM / DOC, greatly reducing the toxic and side effects on the body.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial manufacture and application, and specifically relates to a nanomicelle that targets folic acid and releases chemotherapeutic drugs in response to Cherenkov radiation, and is used to synergize with X-rays for radiotherapy synergy. Background technique [0002] At present, radiotherapy and chemotherapy are still the standard treatment strategy for many cancer patients in clinical application, which can achieve effective control of local lesions and prolong the survival of patients. And synchronous chemotherapy in the process of radiotherapy has a good prognosis effect on the treatment of advanced rectal cancer, cervical cancer, non-small cell lung cancer, head and neck cancer and other cancers. However, the synergistic treatment of radiotherapy and chemotherapy still has obvious systemic toxicity, which is mainly due to the lack of targeted enrichment ability of general chemotherapy drugs, whic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/704A61K47/54A61K47/34A61K47/22A61P35/00
CPCA61K9/1075A61K31/704A61K47/22A61K47/34A61K47/54A61P35/00
Inventor 姚翠萍李炯王斯佳王晶辛静张镇西
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com