Biochemical analyzer

A biochemical analyzer and casing technology, applied in the field of biochemical analyzers, can solve the problems of waste of manpower and material resources, cumbersome and inefficient operation process, etc., achieve the effects of saving manpower and material resources, solving complex operations, and improving detection accuracy

Inactive Publication Date: 2020-08-14
DYNAMIKER BIOTECH TIANJIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the identification and diagnosis methods for pathogenic fungi mainly include pathological biopsy or direct microscopic examination of clinical specimens, pathogen isolation and culture identification. In the field of diagnosis, laboratory, and food safety monitoring, it is often necessary to complete the sampling of micro samples, the filling of precise quantitative reagents, and the use of series of pipetting instruments, all of which require special laboratories and a large number of corresponding laboratory instruments. Complicated and inefficient, waste of manpower and material resources

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Embodiment 1

[0075] Such as Figure 1-Figure 10 As shown, the present invention provides a biochemical analyzer, including a casing 1 , a sample feeding mechanism 2 , a rotating mechanism 3 , a pipetting mechanism 4 , an analyzing mechanism 5 , a sample discharging mechanism 6 and a sample discharging box 7 . Wherein, the casing 1 is provided with a sample inlet and a sample outlet, and the sample inlet mechanism 2 is arranged in the casing 1, and the detection card containing the sample and the reagent can be introduced into the casing 1 from the sample inlet, and the rotating mechanism 3 is set in the casing 1, which can hold multiple detection cards and drive the detection cards to rotate. The sample feeding mechanism 2 can clamp the detection cards on the rotating mechanism 3. The liquid transfer mechanism 4 is set in the casing 1 and is located at Above the rotating mechanism 3, the sample on the detection card can be mixed with the reagent. The analysis mechanism 5 is arranged in the...

Embodiment 2

[0105] After the bacterial endotoxin enters the human body through the digestive system, it is inactivated by the Kupffer cells of the liver and will not cause damage to the body; when it enters the blood in large quantities, it will cause a fever reaction, directly produce toxicity to the cell biofilm, and be mediated by mononuclear macrophages. The induced phagocytosis of the body causes the body to excessively release a variety of inflammatory mediators, thereby affecting cell metabolism, eventually leading to cell death, and in severe cases, it can cause multiple organ failure and death.

[0106] The detection of bacterial endotoxin is based on the detection method of Limulus reagent. The basic principle is that bacterial endotoxin specifically activates factor C in Limulus reagent, activated factor C activates factor B, activated factor B activates procoagulase, and procoagulase is hydrolyzed significantly. The color substrate produces free p-nitroaniline (PNA) to cause th...

Embodiment 3

[0129] After invasive fungi invade deep tissues, organs or blood of the human body, the body can release (1-3)-β-D glucan from the fungal cell wall into blood or body fluids through phagocytosis of phagocytic cells or treatment with digestive enzymes. Therefore, detection of (1-3)-β-D glucan content in blood has important reference value for early diagnosis of invasive fungi.

[0130] At present, the most commonly used clinical diagnostic method is the limulus reagent detection method. The basic principle is that (1-3)-β-D glucan (βG) activates G factor, and the activated G factor activates procoagulase into coagulase, coagulation The enzyme hydrolyzes Limulus tripeptide (Boc-Leu-Gly-Arg-PNA) to produce free p-nitroaniline (PNA). PNA makes the solution yellow, so by detecting the absorbance at 405nm, the invasion is diagnosed according to the change of the solution absorbance Sexual fungal infection.

[0131] (1) In this embodiment, first, the treatment solution, the reconsti...

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Abstract

The invention belongs to the technical field of medical equipment. The invention discloses a biochemical analyzer. The device comprises a shell, a sample feeding mechanism, a rotating mechanism, a pipetting mechanism, an analysis mechanism, a sample discharging mechanism and a sample discharging box; a sample inlet and a sample outlet are formed in the shell; the sample feeding mechanism is arranged in the shell and can guide a detection card containing a sample and a reagent into the shell from the sample inlet; the rotating mechanism can clamp a plurality of detection cards and drive the detection cards to rotate; the sample feeding mechanism can be used for clamping the detection cards on the rotating mechanism; the pipetting mechanism can mix a sample on the detection card with a reagent; the analysis mechanism can analyze samples through detection rays; the sample discharging mechanism is used for moving the detection cards out of the rotating mechanism; the sample discharging boxis arranged at the sample outlet in a sliding mode and used for containing the detected detection cards; and the sample discharging mechanism can guide the detection cards into the sample dischargingbox. According to the invention, a plurality of samples can be inspected and analyzed in a full-automatic, simple and efficient manner, and manpower and material resources are saved.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to a biochemical analyzer. Background technique [0002] Invasive fungal disease (IFD), also known as invasive fungal infection, refers to the pathological changes and pathophysiological processes in which fungi invade human tissues and blood, grow and reproduce in them, leading to tissue damage, organ dysfunction and inflammatory response . Common invasive fungal diseases include invasive candidiasis, aspergillosis, cryptococcosis, marneffei cyanosis, and capsular histoplasmosis. At present, the identification and diagnosis methods for pathogenic fungi mainly include pathological biopsy or direct microscopic examination of clinical specimens, pathogen isolation and culture identification. In the field of diagnosis, laboratory, and food safety monitoring, it is often necessary to complete the sampling of micro samples, the filling of precise quantitative reagents, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/00G01N35/02G01N35/10
CPCG01N35/00G01N35/00732G01N35/025G01N35/1009G01N2035/00465
Inventor 王保学丁真真苗苗周泽奇粟艳
Owner DYNAMIKER BIOTECH TIANJIN
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