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Application of Wubi Shanyao pills to preparation of POI (premature ovarian insufficiency) treatment drug

A technology for ovarian function and yam pills, applied in the directions of drug combination, sexual diseases, pill delivery, etc., can solve the problem of unclear pathogenesis, and achieve the effect of reducing LH level, shortening estrous cycle days, and increasing grasping force

Inactive Publication Date: 2020-08-11
HANGZHOU HUQINGYUTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the specific pathogenesis of POI is still unclear, there is no effective way to restore ovarian function (Xie Xing, Kong Beihua, Duan Tao. Obstetrics and Gynecology (9th Edition) [M]. People's Health Publishing House, 2018)
In addition, because ovarian function decline is a gradual process, and clinical studies have also confirmed that the degree of ovarian function decline is not static, but a process of gradual and fluctuating changes, so it is also a good choice for the intervention of premature ovarian insufficiency (POI). and treatment brings many uncertainties
[0007] To sum up, it is a technical problem that has not yet been studied and solved by those skilled in the art whether the Bishan Yao Pill can be used to treat or improve premature ovarian insufficiency and bring good news to POI patients

Method used

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  • Application of Wubi Shanyao pills to preparation of POI (premature ovarian insufficiency) treatment drug
  • Application of Wubi Shanyao pills to preparation of POI (premature ovarian insufficiency) treatment drug
  • Application of Wubi Shanyao pills to preparation of POI (premature ovarian insufficiency) treatment drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The prescription and preparation of embodiment 1 incomparable yam pill

[0032] The traditional Chinese medicine composition of the present invention is Bibiyam Pills. The prescription composition is as follows (in parts by mass): 15-45 parts of Chinese yam, 5-15 parts of Rehmannia glutinosa, 15-45 parts of Eucommia ulmoides, 20-60 parts of Cistanche, 5-15 parts of Cornel officinalis 5-15 parts of Poria cocos, 15-45 parts of dodder, 5-15 parts of Morinda officinalis, 5-15 parts of Alisma, 5-15 parts of Achyranthes bidentata, 10-20 parts of Schisandra chinensis, and 5-15 parts of red stone fat.

[0033] Specifically, the best prescription and content of the incomparable yam pills are as follows (in parts by mass): 300g (30 parts) of yam, 100g (10 parts) of Rehmannia glutinosa, 300g (30 parts) of Eucommia ulmoides, 400g (40 parts) of Cistanche deserticola, Cornus officinalis 100g (10 parts), Poria cocos 100g (10 parts), Cuscuta 300g (30 parts), Morinda officinalis 100g (1...

Embodiment 2

[0051] Example 2 Effect of Bibiyam Pills on POI Model Mice

[0052] 1. Experimental background

[0053] Tripterygium glycosides (GTW) is the aqueous chloroform extract of the root core of Tripterygium wilfordii, which has immunosuppressive, anti-tumor, and anti-inflammatory effects, but its side effects are also very obvious, especially premature ovarian insufficiency caused by drug overdose , There have been many reports of adverse reactions.

[0054] Clinical studies have shown that tripterygium glycosides can lead to POI, and patients present with irregular menstruation or amenorrhea, E 2 Decreased levels, and increased FSH and LH levels (Yang Juan, Dong Jiangchuan, Han Bing. Effects of tripterygium wilfordii polyglycosides on female reproductive endocrine system [J]. Chinese Journal of Pharmacology and Toxicology, 2006, 20(5): 437-440).

[0055] Modern pharmacological results also show that Tripterygium wilfordii polyglycosides can cause POI animal models, the model ani...

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Abstract

The invention discloses application of Wubi Shanyao pills to preparation of a POI (premature ovarian insufficiency) treatment drug. The Wubi Shanyao pills are prepared from rhizoma dioscoreae, herba cistanche, fructus schizandrae, semen cuscutae, cortex eucommiae, radix achyranthis bidentatae, rhizoma alismatis, radix rehmanniae praeparata, fructus corni, poria cocos, radix morindae officinalis and halloysitum rubrum. A female ICR mouse is subjected to intragastric administration by adopting tripterygium glycosides for 10 weeks to induce POI, molding is carried out, then the model mouse is continuously subjected to intragastric administration by adopting the Wubi Shanyao pills for 12 weeks, it is found that compared with a model control group, the Wubi Shanyao pill administration group hasthe advantages that the holding power of the model mouse can be obviously increased, the average estrous cycle days are shortened, the number of granular cell layers and the number of preantral follicles and sinus follicles are increased, the serum LH level is reduced, the Wubi Shanyao pills have a remarkable improvement effect on the POI mouse, so that the POI treatment or improvement effect isachieved, and good news is brought to the POI patient.

Description

technical field [0001] The technical field of the traditional Chinese medicine preparation of the present invention specifically relates to the application of a kind of Bishan Yao pill in the preparation of a medicine for treating premature ovarian insufficiency, which is the development of a new application of an old medicine. Background technique [0002] Incomparable Yam Pills, formerly known as "Incomparable Yam Pills", first appeared in Tang Dynasty's "Prescriptions for Emergencies and Dry Gold", "curing all kinds of deficiency and damage", and later changed the name to "Yam" because of the taboo word "Yam", so "Tai Ping Hui" "Minheji Bureau Prescription" was changed to "Incomparable Shanyao Pill" when it was collected, and it continues to this day. [0003] As a classic prescription, Bishanyao Pill is composed of 12 traditional Chinese medicines, and its components and contents are as follows: 300g (30 parts) of Chinese yam, 100g (10 parts) of Rehmannia glutinosa, 300g...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/20A61P15/00A61K33/26
CPCA61K36/8945A61K36/64A61K36/79A61K36/57A61K36/39A61K36/43A61K36/46A61K36/21A61K36/884A61K36/804A61K36/40A61K36/076A61K36/746A61K33/26A61K9/2068A61K9/2059A61P15/00
Inventor 陈炜李玉芳朱加明洪亚男
Owner HANGZHOU HUQINGYUTANG PHARM CO LTD
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