Use of a mek inhibitor combined with an androgen receptor antagonist in the preparation of a drug for treating tumors
An androgen receptor and inhibitor technology, applied in the field of medicine
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[0046] Example 1. Study on the efficacy of the compound (drug A) represented by formula (II) as a single drug or in combination with the compound p-toluenesulfonate (drug B) represented by formula (I) on the castrated prostate cancer mouse model. The main observation indicators are:
[0047] Tumor volume, and relative tumor inhibition rate, TGI (%), the calculation formula is:
[0048] TGI%=(1-T / C)×100% (T and C are the relative tumor volume (RTV) or tumor weight (TW) of the treatment group and the control group at a specific time point, respectively).
[0049] In this experiment, drug A was prepared according to the method disclosed in CN103958480A; drug B was prepared according to the method disclosed in patent CN106795116A.
[0050] Cell culture: The tumor cell line VCaP was cultured in a medium DMEM (containing 10% fetal bovine serum) at 37° C. in a 5% CO 2 incubator. When the tumor cells grew to the logarithmic growth phase, the tumor cells were collected and resuspende...
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