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Application of sphingosine kinase 1 inhibitor in preparation of medicine for preventing and/or treating secondary brain injury after cerebral hemorrhage

A technology of sphingosine kinase and inhibitor, which is applied in the field of medicine and can solve the problems that the effect has not been reported yet

Pending Publication Date: 2020-07-31
AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the role of sphingosine kinase 1 inhibitors in secondary brain injury after intracerebral hemorrhage has not been reported

Method used

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  • Application of sphingosine kinase 1 inhibitor in preparation of medicine for preventing and/or treating secondary brain injury after cerebral hemorrhage
  • Application of sphingosine kinase 1 inhibitor in preparation of medicine for preventing and/or treating secondary brain injury after cerebral hemorrhage
  • Application of sphingosine kinase 1 inhibitor in preparation of medicine for preventing and/or treating secondary brain injury after cerebral hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This example is a research experiment on the protective effect of sphingosine kinase 1 inhibitor 5C on secondary brain injury after cerebral hemorrhage

[0031] 1. Reagents and animals

[0032] 1.1 Reagent: sphingosine kinase 1 inhibitor 5C (cayman chemical, USA), purchased by Hengshuncheng Biological Co., Ltd., CAS number 120005-55-2, PubChem identification number 11305122, purity>98%, and its molecular weight is 435.65, Molecular formula is C 26 h 45 NO 4 , storage conditions: -20 degrees, away from light, the molecular structure formula is:

[0033]

[0034] The ELISA detection kit of IL-6, IL-1β and TNFα (Nanjing Jiancheng Bioengineering Company, batch numbers are E20160628, 20171134B, 20170945B respectively); IBA-1 polyclonal antibody (lot number 66827-1-Ig) was purchased from Proteintech company; TF polyclonal antibody (batch number ab47981) was purchased from Abcam; GPX4 enzyme activity detection kit and DCFH-DA fluorescent probe were purchased from Beyont...

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Abstract

The invention relates to an application of a sphingosine kinase 1 inhibitor in preparation of a medicine for preventing and / or treating a secondary brain injury after cerebral hemorrhage, and belongsto the technical field of medical technologies. The invention provides the application of the sphingosine kinase 1 inhibitor in the preparation of the medicine for preventing and / or treating the secondary brain injury after cerebral hemorrhage. An existing sphingosine kinase 1 inhibitor 5C is applied to the preparation of the medicine for preventing and / or treating the secondary brain injury aftercerebral hemorrhage. A new source is provided for the preparation of the medicine for preventing and / or treating the secondary brain injury after cerebral hemorrhage, and meanwhile, a new medicinal value of the sphingosine kinase 1 inhibitor 5C is explored. The technology is funded by Guangxi Science and Technology Base and Talent Special Fund (Guike AD18281013) and Guangxi Natural Science Foundation General Program (2020GXNSFAA259036) Guangxi Natural Science Foundation of Youth Fund (2018GXNSFBA138046). The structural formula of the sphingosine kinase 1 inhibitor is shown in the specification.

Description

technical field [0001] The invention relates to the application of a sphingosine kinase 1 inhibitor in the preparation of a drug for preventing and / or treating secondary brain injury after cerebral hemorrhage, and belongs to the technical field of medicine. Background technique [0002] Cerebral hemorrhage is a sudden-onset blood circulation disorder, clinically manifested as transient or permanent dysfunction, and is an important type of stroke. Cerebral hemorrhage deaths in the Chinese population account for about 61.7% of cerebrovascular disease deaths, and its high morbidity and mortality have become the leading cause of death for Chinese people. At present, it is believed that secondary brain injury after cerebral hemorrhage is the main injury mechanism, including neurotoxicity of red blood cell degradation products, thrombin, inflammation, edema, blood-brain barrier damage, etc. The above factors lead to cell death such as apoptosis, necrosis, and autophagy. cause irr...

Claims

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Application Information

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IPC IPC(8): A61K31/421A61P7/04A61P9/10A61P25/00
CPCA61K31/421A61P7/04A61P9/10A61P25/00
Inventor 廖儒佳李清华刘开祥唐坤蒋艳林田宁廖红展朱金勇
Owner AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
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