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Method and system for establishing biological edge identification system

A technique for establishing methods and markers, applied in the field of computational systems biology and bioinformatics, to achieve strong biologically meaningful effects

Pending Publication Date: 2020-06-19
CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI
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  • Abstract
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  • Method and system for establishing biological edge identification system
  • Method and system for establishing biological edge identification system
  • Method and system for establishing biological edge identification system

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[0053] The above-mentioned features and advantages of the present invention can be better understood after reading the detailed description of the embodiments of the present disclosure in conjunction with the following drawings. In the drawings, components are not necessarily drawn to scale, and components with similar related properties or characteristics may have the same or similar reference numerals.

[0054] figure 1 The flowchart of the first embodiment of the establishment method of the bio-edge identification system of the present invention is shown. See figure 1 The implementation steps of the method for establishing the bio-edge identification system in this embodiment are as follows.

[0055] Step S11: Collect data with two states.

[0056] Data with dual states include: normal state data and disease state data, transfer state data and non-metastatic state data, data with drug resistance state and data without drug resistance state. The data types of data with t...

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Abstract

The invention discloses a method and a system for establishing a biological edge identification system. The change of key interaction can be simply and efficiently found out to serve as a biological identifier of disease occurrence and development. According to the technical scheme, the method comprises the following steps: collecting dual-state data; selecting a gene pair of which the correlationmeets a significant difference condition; for the gene pairs with the correlation meeting the significant difference condition, converting expression value data of the gene pairs into edge data representing the correlation through matrix transformation; and finding out the gene pair with the optimal classification capability in the edge data by applying a feature selection algorithm, and taking the gene pair with the optimal classification capability as a biological edge identifier, thereby establishing a biological edge identification system.

Description

[0001] The present invention is a divisional application of the invention patent application with the application number 201410640410.2 and the invention name "Method and System for Establishing Biological Edge Identification System" filed on November 13, 2014. technical field [0002] The invention relates to computational system biology and bioinformatics, in particular to a method and a system for processing biomarkers. Background technique [0003] The study of biomarkers has always been an important topic in the field of biomedicine. A successful biomarker can help doctors make an accurate diagnosis or propose an effective treatment plan. Therefore, finding a suitable biomarker is very important for overcoming diseases, especially complex diseases. significance. [0004] Human complex diseases are a general term for a class of diseases with unclear etiology, many factors involved, and no effective treatment, such as various types of cancer and diabetes. Since the 1980s...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B40/00G06N20/10
Inventor 陈洛南张万纬
Owner CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI
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