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Receptor-ligand system analysis method influencing intercellular communication

An analytical method, receptor technology, applied in the field of bioinformatics, which can solve problems such as time-consuming, single interaction, etc.

Active Publication Date: 2020-06-19
上海源兹生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although it has been shown that cells can communicate through receptor-ligand binding, most studies are based on functional experiments, which are time-consuming and limited to a single interaction at a time

Method used

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  • Receptor-ligand system analysis method influencing intercellular communication
  • Receptor-ligand system analysis method influencing intercellular communication
  • Receptor-ligand system analysis method influencing intercellular communication

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Embodiment Construction

[0029] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention.

[0030] see figure 1 . It should be noted that the diagrams provided in this embodiment are only schematically illustrating the basic idea of ​​the present invention, and only the components related to the present invention are shown in the diagrams rather than the number, shape and shape of the components in actual implementation. Dimensional drawing, the type, quantity and proportion of each component can be changed arbitrarily during actual implementation,...

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Abstract

The invention relates to bioinformatics, in particular to a receptor-ligand system analysis method influencing intercellular communication. The invention provides an analysis method which comprises the following steps: carrying out primary clustering analysis on cells according to provided gene expression quantitative data; carrying out differential gene expression analysis on the provided cell population; screening the provided differential genes; providing enriched pathways and / or biological processes according to the provided relationship pairs of ligands and receptors; and / or, according tothe provided differential genes and the provided relationship pairs of the ligands and the receptors, providing the inter-cell population communication relationship corresponding to the relationshippairs of the ligands and the receptors. The analysis method provided by the invention is based on single cell sequencing instead of traditional RNA-seq, can deeply understand transcriptome under single cell resolution, can deeply understand tumor heterogeneity, and can further construct a prognosis risk model in combination with an external common data set.

Description

technical field [0001] The present invention relates to bioinformatics, in particular to a receptor-ligand system analysis method affecting intercellular communication, the analysis method is based on single-cell sequencing. Background technique [0002] The tumor microenvironment is composed of a variety of cells, including malignant cells, stromal cells, and immune cells, and the heterogeneity of each cell type (such as different clones of tumor cells or various subpopulations of immune cells) further increases the tumor cell complexity. Sexually, these different cell types all communicate with each other through ligand-receptor interactions. Furthermore, communication between these different types of cells has been implicated in mechanisms of tumorigenesis, progression, drug resistance, immune infiltration, and inflammation. Given the importance of ligand-receptor interactions for patient prognosis, the importance of target cell-cell interactions Therapeutic approaches h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/50G16B25/10G16B40/30
CPCG16B20/50G16B40/30G16B25/10Y02A90/10
Inventor 桑运霞左冰云宋青芳吴崇超
Owner 上海源兹生物科技有限公司
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