Classification of periodontitis patients

A technology for periodontitis and patients, applied in the field of oral care, which can solve problems such as inability of consumers to perform

Pending Publication Date: 2020-06-16
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the available methods for such an assessment involve a labor-intensive process, i.e. the dentist will not perform a routine examination on each patient and / or at each visit, and the consumer cannot perform it (self-diagnosis)

Method used

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  • Classification of periodontitis patients
  • Classification of periodontitis patients
  • Classification of periodontitis patients

Examples

Experimental program
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Effect test

Embodiment Construction

[0037] In a general sense, the present invention is based on the judicious insight to apply clustering techniques to a reference set of patient data, and then further differentiate the set of biomarkers to be applied. This is particularly helpful in addressing the inherent heterogeneity of the patient population.

[0038] A reference set can be obtained by collecting samples of oral fluid, such as saliva, from patients known to have periodontitis. This knowledge can be based on different diagnoses, especially in a routine way, such as during an examination by a dentist or other dental healthcare professional. Concentrations of HGF, MMP8, MMP9 were measured against the reference set. Clustering techniques are then performed on the results. The clustering technique may refer to any such technique known to the skilled person. Thus, for example, the "k-means" clustering technique can be applied to concentration readouts of HGF, MMP8 and MMP9. This results in cluster centers be...

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Abstract

Disclosed is a system, a kit, a use and an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The system and method are based on the insight to apply a clustering technique to a reference set of patient data, and then further discriminating the sets of bio markers to be applied. The clusters are determined on the basis of the biomarkers Hepatocyte Growth Factor (HGF), Matrix metalloproteinase 8 (MMP8), and Matrix metalloproteinase 9 (MMP9). The actual classification of the patient is done on the basis of the measurement of the concentrations of either of two sets of biomarkers. For one cluster these are Interleukin-1beta (IL1beta), Interleukin- 6 (IL6), and Collagen Telopeptide. For the other cluster, these are HGF and metallopeptidase inhibitor 1 (TIMP1).

Description

technical field [0001] The present invention is in the field of oral care and relates to the diagnosis of periodontal disease based on biomarkers in oral fluids such as saliva. In particular, the present invention relates to a kit, system, use and method for classifying periodontitis patients as mild or severe periodontitis. Background technique [0002] Periodontitis is a chronic multifactorial inflammatory disease caused by oral microorganisms and characterized by progressive destruction of hard (bone) and soft (periodontal ligament) tissues, eventually leading to tooth loosening and loss. Periodontitis is distinguished from gingivitis, which is a reversible infection and inflammation of the gum tissue. Inflammatory periodontitis is one of the most prevalent chronic human diseases and is the leading cause of tooth loss in adults. In addition to the substantial negative impact of periodontitis on oral health, there is growing evidence that periodontitis has systemic conse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2333/4753G01N2333/5412G01N2333/545G01N2333/78G01N2333/8146G01N2333/96494G01N2800/18
Inventor S·查特杰M·K·J·德加格A·H·里迈勒G·库伊杰曼M·A·范哈特斯坎普P·普雷肖J·J·泰洛尔
Owner KONINKLJIJKE PHILIPS NV
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