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A preparation method of selenium-doped silicon-calcium-phosphorus bioactive mesoporous glass powder

A mesoporous glass, bioactive technology, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problems of low specific surface area of ​​MBG, unfavorable bone tissue integration and angiogenesis, and achieve convenient and effective operation, simple method, The effect of simple preparation conditions

Active Publication Date: 2021-06-08
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the sol-gel method is mainly used to dope Se into MBG for bone repair (CeramicsInternational, 2015, 42(2):3609-3617), and the specific surface area of ​​MBG synthesized by this method is not high (S BET =230~250m 2 / g), which is not conducive to the combination of bone tissue and angiogenesis, thus limiting the application of MBG in bone repair

Method used

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  • A preparation method of selenium-doped silicon-calcium-phosphorus bioactive mesoporous glass powder
  • A preparation method of selenium-doped silicon-calcium-phosphorus bioactive mesoporous glass powder
  • A preparation method of selenium-doped silicon-calcium-phosphorus bioactive mesoporous glass powder

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Example 1: Use an analytical balance to weigh 1 g of analytically pure P123 and disperse it in 2 mol / L concentrated hydrochloric acid with a volume of 50 ml, and stir in a 37°C water bath for 30 min until the solution is clear and colorless. Measure 0.308ml TEP and slowly add it dropwise to the above liquid, keep stirring for 30min, weigh 1.98g Ca(NO 3 ) 2 .4H 2 O was added to the above liquid, and when Ca(NO 3 ) 2 .4H 2 O is completely dissolved, add 0.028g SeO 2 , then slowly add 3.05ml TEOS dropwise, and after all the addition is completed, keep stirring in a water bath at 37°C for 12h. Then the above liquid was transferred to a 100ml polytetrafluoroethylene reactor and subjected to hydrothermal reaction at 100°C for 24h. After cooling to room temperature, discard the supernatant, add absolute ethanol and stir properly, after standing still, discard the supernatant, transfer the powder to a porcelain boat and dry in an electric blast drying oven at 60°C. The c...

Embodiment 2

[0022] Example 2: Use an analytical balance to weigh 1 g of analytically pure P123 and disperse it in 2 mol / L concentrated hydrochloric acid with a volume of 50 ml, and stir in a 37°C water bath for 30 min until the solution is clear and colorless. Measure 0.308ml TEP and slowly add it dropwise to the above liquid, keep stirring for 30min, weigh 1.98g Ca(NO 3 ) 2 .4H 2 O was added to the above liquid, and when Ca(NO 3 ) 2 .4H 2 O is completely dissolved, add 0.056g SeO 2 , then slowly add TEOS dropwise, and after all the addition is completed, keep stirring in a water bath at 37°C for 12h. Then the above liquid was transferred to a 100ml polytetrafluoroethylene reactor and subjected to hydrothermal reaction at 100°C for 24h. After cooling to room temperature, discard the supernatant, add absolute ethanol and stir properly, after standing still, discard the supernatant, transfer the powder to a porcelain boat and dry in an electric blast drying oven at 60°C. The complete...

Embodiment 3

[0023] Example 3: Use an analytical balance to weigh 1 g of analytically pure P123 and disperse it in 2 mol / L concentrated hydrochloric acid with a volume of 50 ml, and stir in a 37°C water bath for 30 min until the solution is clear and colorless. Measure 0.308ml TEP and slowly add it dropwise to the above liquid, keep stirring for 30min, weigh 1.98g Ca(NO 3 ) 2 .4H 2 O was added to the above liquid, and when Ca(NO 3 ) 2 .4H 2 O was completely dissolved, adding 0.112g SeO 2 , then slowly add TEOS dropwise, and after all the addition is completed, keep stirring in a water bath at 37°C for 12h. Then the above liquid was transferred to a 100ml polytetrafluoroethylene reactor and subjected to hydrothermal reaction at 100°C for 24h. After cooling to room temperature, discard the supernatant, add absolute ethanol and stir properly, after standing still, discard the supernatant, transfer the powder to a porcelain boat and dry in an electric blast drying oven at 60°C. The comp...

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Abstract

The invention discloses a preparation method of selenium-doped silicon calcium phosphorus bioactive mesoporous glass powder. This method transforms selenium into SeO 2 Doped into mesoporous glass in the form of , the preparation steps are as follows: P123 is used as template agent, TEP is used as phosphorus source, Ca(NO 3 ) 2 .4H 2 O is the calcium source, TEOS is the silicon source, the powder obtained by the hydrothermal reaction is washed with absolute ethanol, dried, and the template agent is removed by calcination to obtain the selenium-silicon-calcium-phosphorus bioactive mesoporous glass powder. Tests show that: the selenium-doped bioactive mesoporous glass prepared by the present invention has a molar mass ratio of 1-8% of selenium doped, and has a relatively high specific surface area S BET >500m 2 / g and a typical mesoporous structure, the average mesopore diameter distribution is about 6-7nm, and its extract can obviously induce and promote osteogenesis. Based on good in vitro bioactivity and osteogenic effect, this material has broad application prospects in the field of bone tissue engineering.

Description

technical field [0001] The invention relates to the field of manufacturing trace element-doped mesoporous glass powder for bone repair, especially using P123 as template agent, TEP as phosphorus source, Ca(NO 3 ) 2 .4H 2 O is the calcium source, SeO 2 It is a selenium source, TEOS is a silicon source, and a preparation method for synthesizing a selenium-doped bioactive mesoporous glass powder by hydrothermal reaction. Background technique [0002] Human bone tissue defects caused by congenital malformations, diseases, trauma, and aging have become common clinical orthopedic diseases, requiring a large number of bone repair materials to treat them. An ideal bone repair material should have good biocompatibility, non-toxic degradation products and no long-term inflammatory response; can recruit bone marrow stem cells and other related cells; good biodegradability, degradation rate and tissue growth rate match good biological activity . (Acta Biomaterialia, 2013, 9(1):4457...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03C12/00C03C4/00A61L27/10A61L27/54A61L27/56A61L27/58
CPCA61L27/10A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/412A61L2300/602A61L2430/02C03C4/0007C03C12/00
Inventor 尹光福黎小玲李江峰
Owner SICHUAN UNIV
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