Application of basaloxin in the preparation of medicines for driving and killing fish ectoparasites

A technology of salicylic glycosides and a medicine is applied to the application field of salivarius glycosides in the preparation of medicaments for repelling and killing ectoparasites of fish, which can solve the problems of no further salicylic glycosides, differences in structure and biological activity, and the like, and is not easy to achieve. The effect of drug resistance, low fish toxicity, and simple usage

Active Publication Date: 2021-08-10
YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The large differences in the structures of these two classes of compounds may lead to significant differences in their biological activities
Therefore, in the prior art, only related to the extract of the willow and C 21 The new steroid glucoside compounds are used in the control of agricultural pests, and there is no further report on the use of glucosides in the control of parasites in aquatic fish

Method used

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  • Application of basaloxin in the preparation of medicines for driving and killing fish ectoparasites
  • Application of basaloxin in the preparation of medicines for driving and killing fish ectoparasites
  • Application of basaloxin in the preparation of medicines for driving and killing fish ectoparasites

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Evaluation of the repelling and killing effect of salivatoxin on third-generation worms of Kobayashi

[0020] 1 Materials and methods

[0021] 1.1 Test animals

[0022] The host model is goldfish (Carassius auratus), weighing 4.85±0.92g, purchased from the Flower and Bird Market, Wuluo Road, Wuchang District, Wuhan City; Live species conservation in the laboratory.

[0023] 1.2 Test drug and preparation

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PUM

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Abstract

The invention belongs to the field of fish parasite medicines, and discloses the application of salicylotin in the preparation of medicines for expelling and killing third-generation fish ectoparasites. Basaloxin is derived from natural plants, has no residue, no pollution, no pollution, is easy to degrade in the environment, and can kill all parasites at one time within the effective dose range, achieving the effect of preventing and controlling three generations of entomorrhoids. At the same time, the half-lethal concentration of glucotoxin on fish is 12.7 times the half-effective concentration for killing third-generation insects, and it is safe for fish within the range of effective insecticidal doses. This ratio is much higher than the most commonly used third-generation insect disease control. The ratio of drug--formalin (LC50 / EC50=4.2), this compound has a broad application prospect of being developed into a new type of environmentally friendly fishing drug for preventing and controlling fish ectoparasites.

Description

technical field [0001] The invention belongs to the technical field of fish parasite medicines, and relates to the new application of salivatoxin, in particular to the application of salivatoxin in the preparation of medicines for expelling and killing fish ectoparasites (especially third-generation worms). [0002] technical background [0003] Tertiary worms are one of the most common fish parasites in aquaculture, generally parasitic on the body surface, fin rays and gills of fish. Infection of a large number of third-generation worms can lead to obvious symptoms such as fin erosion, thickened skin, and difficulty in breathing of the host fish, and the adsorption organ of the third-generation worm - the posterior haustoria can destroy the integrity of the skin of the host fish, thereby causing bacteria, fungi, etc. Secondary infections such as viruses and viruses cause great harm to host fish. In order to effectively control the third-generation insect disease, domestic a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P33/14
CPCA61K31/7048A61P33/14
Inventor 周顺艾晓辉刘永涛董靖胥宁杨秋红杨移斌
Owner YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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