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Application of norisoboldine in preparing drugs for preventing and/or treating bladder smooth muscle dysfunction

A technology of desmethylisoboldine and dysfunction, which is applied in the field of bladder smooth muscle dysfunction treatment, can solve the problems of unsatisfactory curative effect and the limitation of clinical application of anticholinergic drugs, and achieve the goal of reducing contractility, contraction and good regulation Effect

Active Publication Date: 2020-05-22
DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the treatment methods for overactive bladder mainly include behavior therapy, drug therapy, neuromodulation therapy, etc. In severe cases, detrusor muscle transection or bladder enlargement surgery can be used, but the curative effect is not satisfactory, and the side effects of anticholinergic drugs are limited to a certain extent. also limits its clinical application

Method used

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  • Application of norisoboldine in preparing drugs for preventing and/or treating bladder smooth muscle dysfunction
  • Application of norisoboldine in preparing drugs for preventing and/or treating bladder smooth muscle dysfunction
  • Application of norisoboldine in preparing drugs for preventing and/or treating bladder smooth muscle dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Effects of desmethylisoboldine on contractility of detrusor muscle

[0034] Take the mouse bladder, cut the bladder longitudinally into 4 parts with a scalpel (each size is 5-10mm×1-5mm), and tie the two ends of each part into a loop with No. 6 surgical thread, and one end is attached to a fixed On the hook, while the other end is connected to the tension sensor to measure the tension (Harvard Apparatus, USA), the tissue is immersed in an organ bath containing Kreb's solution, the solution is maintained at 37 ° C, and oxygen is continuously passed. The gas composition is as follows: 950mL / L O 2 +50mL / L CO 2 . After acclimatization for 0.5 h in a tension-free state, the bladder tissue was stretched to a tension of 0.5 g and equilibrated for 1 h. Tension changes were displayed on a physiological recorder (Harvard Apparatus, USA & LabChart, New Zealand), and the data were recorded by software (LabChart Software).

[0035] After equilibration, nerve-mediated contraction...

Embodiment 2

[0037] Effects of desmethylisoboldine on the contractility of bladder smooth muscle (DSM) in mice

[0038] 1) Take the mouse bladder, and use a scalpel to cut the bladder longitudinally into 4 parts (5-10 mm x 1-5 mm in size each), and tie the two ends of each part into loops with No. 6 surgical thread, and attach one end to the On the fixed hook, while the other end is connected to the tension sensor to measure the tension (Harvard Apparatus, USA), the tissue is immersed in an organ bath containing Kreb's solution, the solution is maintained at 37 ° C, and oxygen is continuously passed, and the gas composition As follows: 950mL / L O 2 +50mL / L CO 2 . After acclimatization for 0.5 h in a tension-free state, the bladder tissue was stretched to a tension of 0.5 g and equilibrated for 1 h. Tension changes were displayed on a chart recorder (Harvard Apparatus, USA & LabChart, New Zealand) and data were recorded by software (LabChart Software). After tension balance, observe the ...

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Abstract

The invention provides application of norisoboldine in preparing drugs for preventing and / or treating a bladder smooth muscle dysfunction, and belongs to the technical field of treatment of the bladder smooth muscle dysfunction. The norisoboldine has a very good and obvious regulating function on a bladder smooth muscle function, can lower the contraction ability of detrusor, obviously reduces a contraction response caused to alpha, beta-methylene adenosine 5'-triphosphate (ATP), CCh and KCl by the detrusor, can further obviously reduce contraction caused by electrical field stimulation (EFS),can be used for treating overactive bladder, and can also be used for treating various diseases including uroclepsia, hyperuresis and the like.

Description

technical field [0001] The invention belongs to the technical field of treatment of bladder smooth muscle dysfunction, and in particular relates to the application of desmethylisoboldine in the preparation of medicaments for preventing and / or treating bladder smooth muscle dysfunction. Background technique [0002] The bladder has the functions of storing urine and urinating, and these two functions are realized by the relaxation and contraction of smooth muscle under the regulation of nerves and receptors. Maintaining normal relaxation and contraction of the detrusor muscle is particularly important for maintaining normal urine storage and urination, and changes in bladder function are one of the important factors that cause symptoms of lower urinary tract diseases such as frequent urination, urgency, and urinary incontinence. Alteration of smooth muscle function is not only an important pathogenesis of bladder overactivity or detrusor overactivity, but also a necessary con...

Claims

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Application Information

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IPC IPC(8): A61K31/473A61P13/00A61P13/02A61P13/10
CPCA61K31/473A61P13/00A61P13/02A61P13/10
Inventor 操红缨
Owner DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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