Benzo[f]cyclopenta[c]quinoline derivatives and their application

Abstract

The invention discloses a benzo[f]cyclopenta[c]quinoline derivative and application thereof in preparation of a medicine for treating prostatic cancer, and belongs to the field of medicines. The benzo[f]cyclopenta[c]quinoline compound with the structural formula as shown in the formula (I) has obvious antagonistic activity on an androgen receptor, can be used as an androgen receptor antagonist tobe applied to treatment of androgen receptor related diseases, and provides a new choice for development of drugs for treating prostatic cancer at present.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to benzo[f]cyclopenta[c]quinoline derivatives and their medical applications, in particular to the use of benzo[f]cyclopenta[c]quinoline derivatives in the preparation of androgen Use of receptor antagonists in the treatment of prostate cancer. Background technique [0002] Prostate cancer is one of the most common and fatal tumors in men worldwide. In my country, with the improvement of people's living standards and changes in diet structure, the incidence of prostate cancer is increasing year by year. Due to the lack of obvious clinical symptoms and insidious onset of prostate cancer in the early stage, it is difficult to popularize screening, and most patients are already in the middle and late stage of the tumor when confirmed, accompanied by tissue invasion and metastasis, and the best treatment opportunity for radical prostatectomy has been missed. [0003] Targeted drug therapy is an ...

AI Technical Summary

Problems solved by technology

However, the generation of inherent or acquired drug resistance, and the excessive similarity of chemical structures of marketed drugs make multiple antagonists face simultaneous drug resistance

In addition, there are very few alternative drugs, which seriously restricts the clinical application and selection of such antagonists.

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