A compound preparation for treating skin inflammation and its preparation method

A compound preparation and skin inflammation technology, which is applied in the fields of Uyghur medicine and ethnic medicine, can solve the problems of telangiectasia, aggravation of symptoms, skin atrophy, etc., and achieve the effect of not easy to relapse, no drug resistance, and quick effect

Active Publication Date: 2021-12-21
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At this stage, external use of glucocorticoids is usually used for the treatment of patients with eczema and dermatitis, but long-term application can easily lead to skin atrophy and promote telangiectasia, which will aggravate symptoms and may induce infection. Therefore, in terms of clinical effects and adverse reactions Considering other aspects, the advantages of using traditional Chinese medicine for the treatment of eczema and dermatitis patients are obvious.

Method used

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  • A compound preparation for treating skin inflammation and its preparation method
  • A compound preparation for treating skin inflammation and its preparation method
  • A compound preparation for treating skin inflammation and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1000g was prepared as the base to prepare ointments)

[0033] Table 1

[0034]

[0035] a, a ratio in Table 1 and Coptis Rumex, pulverized to 40 mesh were mixed, followed by extraction with 20-fold concentration of 70% ethanol at a temperature of 50 ℃, extracted twice, extraction time was 2 hours, combined The extract was filtered, to obtain an alcohol extract;

[0036] B, gallic and roses were crushed to 100 mesh mix was extracted with water 15 times, a temperature of 50 ℃, extracted twice, each extraction time was 2 hours, and the combined extracts were filtered to obtain an aqueous extract liquid;

[0037] C, step a and step b, extract the aqueous alcohol extract were concentrated under reduced pressure at a temperature of 40 ℃ to extract the relative density of 1.05, was dried in vacuo and pulverized to obtain ethanol extract and water soluble extract powder pink;

[0038] d, in the step (c) propylene glycol plus ethanol extract powder were mixed to prepare a solutio...

Embodiment 2

[0041] (1000g was prepared as the base to prepare ointments)

[0042] a, a ratio in Table 1 will berberine and Rumex, were crushed to 100 mesh were mixed extract of 70% ethanol 8-fold concentration at a temperature of 100 deg.] C, extracted three times, the extraction time was 1.5 hours and the combined extracts , filtered to give the alcohol extract;

[0043] B, gallic and roses were mixed pulverized to 10 mesh, was extracted with 8-fold amount of water at a temperature of 100 deg.] C, extracted three times, each extraction time of 1.5 hours, the combined extract was filtered, to obtain an aqueous extract liquid;

[0044] C, step a and step b the alcohol extract in aqueous extracts were concentrated under reduced pressure to extract the relative density is 1.10 at temperature 60 ℃, ethanol extract and obtain water soluble extract;

[0045] d, in the step (c) propylene glycol plus ethanol extract were mixed to prepare a solution A, the standby;

[0046] E, Purified water is heated...

Embodiment 3

[0048] (1000g was prepared as the base, prepared gels)

[0049] Table 2

[0050]

[0051] a, a ratio in Table 2 and will Rumex berberine, were crushed to 100 mesh and thoroughly mixed, followed by extraction with 50% ethanol at a concentration of 5 times, the temperature is 30 ℃, extracted twice, each extraction time was 2 hours The combined extracts were filtered to give the alcohol extract;

[0052] B, gallic and roses were crushed to 100 mesh, mixed thoroughly, extracted with 5 times the amount of water, temperature 30 ℃, extracted twice, each extraction time was 2 hours, the combined extracts were filtered to give water Intake extract;

[0053] C, step a and step b alcohol extract aqueous extracts were concentrated under reduced pressure to extract the relative density is 1.10 at temperature 60 ℃, ethanol extract and obtain water soluble extract;

[0054] d, in step c ethanol extract and propylene glycol were mixed to prepare a solution A, the standby;

[0055] E, carbomer u...

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PUM

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Abstract

The invention relates to a compound preparation for treating skin inflammation and a preparation method thereof. The raw materials of the preparation are Coptis chinensis, rhubarb rhubarb, rose, and gall, which are extracted by solvent, impurity removal, concentration or drying, and medically acceptable auxiliary materials. Made into ointments, gels, tinctures, varnishes or liniments. The compound preparation has antibacterial, anti-inflammatory and astringent effects, and is used for treating skin inflammations including acute and chronic eczema, atopic dermatitis, contact dermatitis and allergic dermatitis. Pharmacodynamic studies have shown that the compound preparation of the present invention effectively inhibits NO activity, can inhibit the release of NO, can significantly reduce the degree of inflammation of skin lesions, and can increase IL-2, IL-4, The level of IL-18 is reduced, and the level of TNF-α and IL-12 caused by dermatitis and eczema is reduced, and the balance of Th1 cells and Th2 cells is achieved, which plays a therapeutic role.

Description

Technical field [0001] The present invention relates to a compound and its preparation method of treating inflammation of the skin, especially in the manufacture of a pharmaceutical compound in the treatment of eczema, and belongs to the pharmaceutical technical field Uygur national medicine. Background technique [0002] Eczema is caused by a variety of external factors a severe itching skin inflammation. Sub-acute, subacute, chronic three. With acute bleeding tendency, the chronic infiltration, hypertrophy. Some patients direct manifestations of chronic eczema. Lesions have pleomorphic, symmetry, itching and ease of repeated attacks and so on. Modern research has found that the cause of eczema and genetic factors, blood circulation disorders, psychological factors, metabolic factors, environmental factors (air, pollen, etc.), restaurants and bacterial infections related to the pathogenesis of complex, mainly related to the immune system in a variety of cytokines closely related...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/738A61P17/00A61P37/08A61P29/00A61K35/64
CPCA61K36/718A61K36/70A61K36/738A61K35/64A61K9/0014A61K47/32A61K47/06A61P17/00A61P37/08A61P29/00A61K2236/333A61K2236/39A61K2236/331A61K2236/51A61K2300/00
Inventor 阿吉艾克拜尔·艾萨凯丽比努尔·艾尔肯吴涛贺飞西尔艾力·吐尔逊
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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