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Callicarpa kwangtungensis Chun extract and application thereof

An extract, the technology of Guangdong purple, is applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2020-04-24
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Guangdong purple pearl extract can significantly inhibit the exudation of experimental inflammation. Traditional Chinese medicine has few side effects, low price and wide sources. At present, there is no literature report that Guangdong purple pearl extract has cardioprotective effect. Therefore, it has been developed to have cardioprotective activity. It is necessary to use traditional Chinese medicine to prevent the occurrence of some cardiovascular diseases

Method used

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  • Callicarpa kwangtungensis Chun extract and application thereof
  • Callicarpa kwangtungensis Chun extract and application thereof
  • Callicarpa kwangtungensis Chun extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The extraction of embodiment 1 Guangdong purple pearl and rough separation

[0030] Grind 5.4kg of raw medicinal material of Guangdong Zizhu into powder, heat and reflux extract with 80% ethanol for 3 times, each time for 1 hour, filter the filtrate with suction and combine them, then concentrate under reduced pressure at 50°C to obtain the total extract, namely Guangdong Zizhu For the total extract of beads, the total extract is passed through the D101 macroporous resin column. The specific method is to mix 400g macroporous resin with 400 grams of total extract, dry the column, and the column volume is 8000ml. Use 30% ethanol Elution, collecting the eluate and concentrating to obtain the extract, namely the total phenylethanol glycosides of Guangdong Zizhu. The amount of total phenylethanol glycosides in the extract is measured by the content of forsythiaside B and golden shicroside, and the liquid phase analysis shows that the content of phenylethanol glycosides in th...

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Abstract

The invention relates to a Callicarpa kwangtungensis Chun extract. The invention discloses that a total extract of Callicarpa kwangtungensis Chun and a phenylethanol glycoside compound enriched from the total extract of Callicarpa kwangtungensis Chun through a macroporous resin column have an anti-myocardial ischemia effect. This part can always play a role in protecting rat myocardial damage by reducing the content of LDH, CK and MDA in serum, increasing the content of GSH in myocardial tissue, increasing the activity of Na<+> / K<+>-ATPase in myocardial tissue and reducing the level of inflammation and apoptosis. Total phenylethanoid glycoside of Callicarpa kwangtungensis Chun exerts the myocardial protection effect through Na<+> / K<+>-ATPase / Src / ERK1 / 2 signaling pathway.

Description

technical field [0001] The invention discloses a traditional Chinese medicine extract for myocardial protection, which belongs to the field of traditional Chinese medicine. Background technique [0002] Myocardial ischemia refers to a disease in which the blood perfusion of the heart is reduced, which will lead to a reduction in the oxygen supply to the heart and abnormal myocardial energy metabolism. Seriously affect people's life and work, severe cases can lead to myocardial infarction and sudden death. It is characterized by hypoxia, myocardial inflammation, and cardiomyocyte apoptosis, resulting in a severe imbalance between myocardial oxygen supply and demand that allows rapid development of myocardial necrosis. The main symptoms of myocardial ischemia are angina pectoris, myocardial infarction, ischemic cardiomyopathy, and sudden death. Cardiovascular diseases (CVDs) are a group of diseases that affect the heart and / or blood vessels, and hypertension and atherosclero...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P9/10A61K135/00
CPCA61K36/85A61K2236/333A61K2236/39A61K2236/55A61P9/10
Inventor 冯锋柳文媛孙晶曲玮段冰静王如意
Owner CHINA PHARM UNIV
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