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New use of sesquiterpenoid for treating gout

A technology for sesquiterpenoids and compounds, which is applied in the field of sesquiterpenoids for the treatment of gout, can solve the problems of large toxic and side effects, increased risk of cardiovascular system diseases, low drug tolerance and the like

Active Publication Date: 2020-01-03
CATCH BIO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the toxic and side effects of the above-mentioned medicines are usually larger, for example: allopurinol can cause severe toxic and side effects such as allergic reactions (10-15% incidence rate), hypersensitivity syndrome, bone marrow suppression; probenecid, benzbroma Longze has side effects such as irritating the gastrointestinal tract, causing renal colic, and triggering acute attacks of gout; febuxostat can increase the risk of cardiovascular system diseases, and in severe cases, Stevens-Johnson syndrome can occur; moreover, the tolerance of the above drugs generally low sex
In summary, these problems limit the clinical application of these drugs to a certain extent

Method used

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  • New use of sesquiterpenoid for treating gout
  • New use of sesquiterpenoid for treating gout
  • New use of sesquiterpenoid for treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Take by weighing 50 kg of dried rhizome of Atractylodes Rhizome, after crushing the dried rhizome of Atractylodes Rhizoma Atractylodes Rhizome, soak and extract 3 times with 90% ethanol solution with a volume fraction of 8 times the volume, concentrate under reduced pressure to remove the organic solvent, and obtain concentrated solution A (solid content in concentrated solution A 2.5kg); the concentrated solution A was passed through a 50L-D101 column (column diameter 22cm × height 150cm), and the volume fractions of 40% and 95% ethanol were used to wash 4 column volumes respectively, and the volume fraction of 95% ethanol was collected. The product was concentrated under reduced pressure to remove the organic solvent to obtain a concentrated solution B (1 kg of solid content in the concentrated solution B), and the concentrated solution B was extracted 3 times with ethyl acetate, and the extraction solvent was recovered under reduced pressure to obtain 400 g of ethyl ac...

Embodiment 2

[0062] Weigh 50 kg of inula chinensis medicinal material, pulverize the inulin inulin, soak and extract 3 times with 8 times the volume of ethanol solution with a volume fraction of 90%, and concentrate under reduced pressure to remove the organic solvent to obtain concentrated solution A; pass the concentrated solution A over 50 L -D101 column (column diameter 22cm × height 150cm), wash 4 column volumes respectively with volume fraction of 40% and 95% ethanol, collect the eluate with volume fraction of 95% ethanol, and concentrate under reduced pressure to remove the organic solvent to obtain Concentrated solution B (solid content in concentrated solution B is 3.2kg), concentrated solution B was extracted with petroleum ether for 3 times, and the extraction solvent was recovered under reduced pressure to obtain 2 kg of petroleum ether extract. The petroleum ether extract was separated by silica gel column chromatography, followed by gradient elution with a mixed solution with ...

Embodiment 3

[0065] Take by weighing 60 kg of the whole herb of Auricularia daflora plant, cut it into pieces, soak and extract 4 times with 6 times the volume of ethanol solution with a volume fraction of 85%, concentrate under reduced pressure to remove the organic solvent, and obtain concentrated solution A; Solution A passes through a 50L-D101 column (column diameter 22cm×height 150cm), washes 4 column volumes with volume fractions of 40% and 95% ethanol respectively, collects eluate with volume fraction of 95% ethanol, concentrates under reduced pressure to remove Organic solvent to obtain concentrated solution B (solid content in concentrated solution B: 1.1kg), concentrated solution B was extracted 3 times with acetone, and the extraction solvent was recovered under reduced pressure to obtain 750 g of acetone extract. The acetone eluate was separated by silica gel column chromatography, followed by gradient elution with a mixed solution with a volume ratio of petroleum ether: ethyl a...

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PUM

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Abstract

The invention belongs to the field of medicines or health products, and particularly relates to a novel use of sesquiterpenoid in reducing uric acid. The sesquiterpenoid has a structure represented byformula (I): wherein X, R1-R11 are as defined in the description of the invention. Through an animal model of hyperuricemia, the sesquiterpenoid of the invention is found to promote uric acid excretion in vivo, has an obvious effect of reducing uric acid, and can be used as a potential medicine for reducing uric acid or treating gout.

Description

technical field [0001] The invention belongs to the field of medicines or health care products, and in particular relates to a new application of sesquiterpenoids for treating gout. Background technique [0002] Uric acid is the final metabolite of human purine compounds, and purine metabolism disorders lead to hyperuricemia. Under a normal purine diet, if the blood uric acid level on an empty stomach is higher than 416 μmol / L for men and 360 μmol / L for women on two different days, it is called hyperuricemia. Gout is a crystal-associated arthropathy caused by the deposition of monosodium urate (MSU), which is directly related to hyperuricemia caused by purine metabolic disorders and / or decreased uric acid excretion. The main clinical manifestation is hyperuricemia , recurrent gouty acute arthritis, gouty chronic arthritis and tophi, gouty nephropathy and renal uric acid stones, etc. In severe cases, joint disability and renal insufficiency may occur. In addition, gout is o...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K31/403A61K31/122A61K31/343A61P19/06A23L33/10A23L33/105
CPCA61K31/365A61K31/403A61K31/122A61K31/343A61P19/06A23L33/10A23L33/105A23V2002/00A23V2200/30A23V2250/21Y02A50/30
Inventor 不公告发明人
Owner CATCH BIO SCI & TECH
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