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Methods of making luminal tissue constructs

一种组织构建体、制造方法的技术，应用在3D生物打印领域，能够解决管腔再狭窄、缺少内皮细胞层、血栓再次发生等问题，达到避免管腔再狭窄、提高生物可靠性、避免血栓的再次发生的效果

Active Publication Date: 2021-08-17
SICHUAN REVOTEK CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the replacement of diseased or damaged blood vessels with this artificial blood vessel has achieved great clinical results, it still faces difficult problems, including the recurrence of thrombus and the occurrence of lumen restenosis after long-term implantation
The root cause of these problems is the lack of an intact layer of endothelial cells on the inner surface of the artificial blood vessel
[0003] In addition, because the artificial blood vessel can hardly be deformed in the radial direction, the existing technology cannot compress the artificial blood vessel externally so that the bio-brick can be completely evenly, completely and flatly attached to the inner wall of the artificial blood vessel

Method used

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  • Methods of making luminal tissue constructs
  • Methods of making luminal tissue constructs
  • Methods of making luminal tissue constructs

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Embodiment Construction

[0063] The technical solutions of the present invention will be described in further detail below with reference to the accompanying drawings and embodiments.

[0064] The specific embodiments of the present invention are for the convenience of further description of the concept of the present invention, the technical problems to be solved, the technical features constituting the technical solution and the technical effects brought about. It should be noted that the description of these embodiments does not constitute a limitation of the present invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

[0065] In the present invention, the term "biological construct" refers to an artificially constructed two-dimensional or three-dimensional structure containing cells. In certain preferred embodiments, the biological construct is a three-d...

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Abstract

The invention relates to a method for manufacturing a luminal tissue construct. The manufacturing method includes: step 1: covering the elastic film on the support; step 3: printing the biological construct on the elastic film; step 5: forming a construct adhesive layer on the biological construct; step 7: placing the luminal tissue Bonded to the construct adhesive layer. According to the manufacturing method of the luminal tissue construct of the present invention, the printed biological construct is assembled on the inner surface of the luminal tissue to form a luminal tissue construct, thereby avoiding the occurrence of thrombus after a long-term implantation of the luminal tissue construct. The emergence of issues such as recurrence and luminal restenosis improves the bioreliability of luminal tissue constructs.

Description

technical field [0001] The invention relates to the technical field of 3D bioprinting, in particular to a method for manufacturing a lumen tissue construct. Background technique [0002] In the prior art, common artificial blood vessels are made of polymer fibers (such as nylon, polyester), silk or expanded polytetrafluoroethylene. During vascular grafting, diseased or damaged blood vessels can be replaced with complete artificial blood vessels. Although the use of artificial blood vessels to replace diseased or damaged blood vessels has achieved great clinical results, it still faces difficult problems, including the recurrence of thrombus and lumen restenosis after long-term implantation. The root cause of these problems is the lack of an intact endothelial cell layer on the inner surface of the artificial blood vessel. [0003] In addition, since the artificial blood vessel can hardly be deformed in the radial direction, the existing technology cannot compress the artif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C64/112B29C64/20B29C64/209B29C64/295B29C64/314B29C64/321B29C64/30B29C64/393B29C64/40B33Y10/00B33Y30/00B33Y40/00B33Y40/10B33Y50/02
CPCB33Y10/00B33Y30/00B33Y40/00B33Y50/02B29C64/112B29C64/20B29C64/209B29C64/295B29C64/30B29C64/321B29C64/393B29C64/40A61F2/06A61F2240/001B33Y70/00B33Y80/00B29C64/106B29C64/245B29C64/35
Inventor 李意军何峻轩胡小林蒋智左潇
Owner SICHUAN REVOTEK CO LTD
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