Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New skeleton large ring mixed peptide polyketide and preparation method and application thereof

A compound and drug technology, applied in the field of new skeleton macrocyclic mixed peptide polyketide compound, can solve the problem of no isolated compound and achieve the effect of inhibiting apoptosis

Active Publication Date: 2019-12-20
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report of isolating the compound of the present invention from Fukang tree

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New skeleton large ring mixed peptide polyketide and preparation method and application thereof
  • New skeleton large ring mixed peptide polyketide and preparation method and application thereof
  • New skeleton large ring mixed peptide polyketide and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, the preparation of compound of the present invention

[0047] 1. Experimental materials

[0048] 1.1 Experimental reagents

[0049] Column chromatography silica gel, 200-300 mesh (experimental grade), Qingdao Haiyang Silica Gel Desiccant Factory.

[0050] MCI gel CHP 20P, 75-150 μm, Mitsubishi Chemical Corporation, Japan.

[0051] gel ODS-A, 50 μm, Japan YMC Company.

[0052] Analytical reagents such as petroleum ether, ethyl acetate, and acetone were purchased from Chengdu Kelong Chemical Reagent Factory.

[0053] 1.2 Experimental Instruments

[0054] Q-TOFII high-resolution time-of-flight mass spectrometer (Bruker, USA);

[0055] Bruker-AV-800 nuclear magnetic resonance instrument (Bruker, Switzerland);

[0056] Fourier transform infrared spectrometer (Perkin-Elmer);

[0057] V-650 UV spectrometer (JASCO);

[0058] RE-2000B rotary evaporator (Shanghai Yarong Instrument Company);

[0059] Perkin-Elmer 341 polarimeter (Perkin-Elmer, USA);

[0060] ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
Login to View More

Abstract

The invention discloses a new skeleton large ring mixed peptide polyketide and a preparation method and application thereof. The invention provides the compound shown as a formula I (please see the specification for the formula I), or a stereoisomer, a crystal form or a pharmaceutically acceptable salt thereof, wherein in the formula I, R is selected from hydrogen, hydroxyl, halogen, C1-C4 alkoxyand C1-C6 alkyl. The invention further provides the preparation method and application of the compound. Experimental results prove that the compound provided by the invention can inhibit apoptosis ofnerve cells, has a neuroprotective effect, can be used as a potential drug for preventing and treating neurodegenerative diseases, and provides a new drug option for clinical application.

Description

technical field [0001] The invention relates to a new skeleton macrocyclic mixed peptide polyketide compound and its preparation method and application. Background technique [0002] Voacanga africana Stapf., also known as African potato fruit, is a plant of the genus Voacanga of the family Apocynaceae, mainly produced in West Africa, Congo, Tanzania and other places. It occupies an important position in the field of African traditional medicine and is often used in the treatment of leprosy, dysentery, generalized edema, convulsions in children, epilepsy, diuretics, and tonics for children. Decoctions of stems and bark were used to treat mental disorders, and the gum was used to granulate calendars. The decoction of the bark is considered an analgesic and is added to bruise medicine. A decoction of the bark and root was also used to treat heart cramps. Decoctions of the bark and roots are also used to treat choking, fruit decoctions are used as a disinfectant, and leaf de...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D267/00A61K31/395A61P25/00A61P25/28
CPCC07D267/00A61P25/00A61P25/28
Inventor 邓赟李鸿翔谭玉柱刘海峰但小梅郭大乐彭腾
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com