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System for predicting probability of poor ovarian response of subject under antagonist regimen, and system for guiding selection of gonadotropin starting medication dose

A subject, follicle stimulating hormone technology, applied in the direction of drug reference, etc., can solve the problems of low ovarian response, low embryo implantation rate, pregnancy rate and live birth rate, adverse pregnancy outcome and other problems

Active Publication Date: 2019-12-13
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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Problems solved by technology

During COS, the main problem faced by patients is insufficient number of oocytes retrieved, i.e. low ovarian response, which leads to high cycle cancellation rate and adverse pregnancy outcomes, such as low embryo implantation rate, pregnancy rate and live birth rate

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  • System for predicting probability of poor ovarian response of subject under antagonist regimen, and system for guiding selection of gonadotropin starting medication dose
  • System for predicting probability of poor ovarian response of subject under antagonist regimen, and system for guiding selection of gonadotropin starting medication dose
  • System for predicting probability of poor ovarian response of subject under antagonist regimen, and system for guiding selection of gonadotropin starting medication dose

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Embodiment

[0153] In the embodiment, the sample size is estimated first, the total sample size should be >553, and all couples are trying to conceive for at least 12 months.

[0154] According to the following inclusion and exclusion criteria, a total of 561 couples were enrolled in the three reproductive medicine centers for this study, that is, 561 couples who met the following inclusion and exclusion criteria were selected for subsequent research.

[0155] The inclusion criteria were: women aged 20-45 years, body mass index (BMI) ≤ 30, six consecutive menstrual cycles of 25-45 days, normal bilateral ovarian morphology assessed by transvaginal ultrasonography, previous IVF / ICSI- ET cycle number ≤ 2.

[0156] The exclusion criteria were: hydrosalpinx, unilateral ovary AFC>20, polycystic ovary syndrome, other untreated metabolic or endocrine diseases, previous surgery for the ovary or uterine cavity, intrauterine abnormalities, pregnancy within 3 months, Smoking, using oral contraceptiv...

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Abstract

The present invention relates to a system for predicting the probability of poor ovarian response of a subject under an antagonist regimen, and a system for guiding the selection of a gonadotropin starting medication dose. The system for predicting the probability of poor ovarian response includes: a data acquisition module for acquiring the age, the anti-Mullerian hormone (AMH) level, the follicle stimulating hormone (FSH) level, the antralfollicle count (AFC) data of the subject; and a module for calculating the probability of poor ovarian response, which is used for calculating the information obtained in the data acquisition module to calculate the probability of poor ovarian response of the subject, and giving a starting dose recommendation for exogenous gonadotropin (Gn) based on thepredicted probability of poor ovarian response.

Description

technical field [0001] The present invention relates to a system for predicting ovarian hyporesponsiveness in a subject under a dosing regimen of an antagonist, and a system for guiding the starting dose range of gonadotropins (Gn). Background technique [0002] In the process of controlled ovulation induction (COS), the number of retrieved eggs is considered to be a powerful predictor of successful pregnancy after IVF-ET (in vitro fertilization-embryo transfer). A study of more than 400,000 people in Europe published in the authoritative journal "Human Reproduction" showed that compared with a lower number of eggs retrieved on the day of egg retrieval, the appropriate number of eggs retrieved significantly increased the live birth rate. During COS, the main problem faced by patients is the insufficient number of oocytes retrieved, that is, low ovarian response, which leads to high cycle cancellation rate and adverse pregnancy outcomes, such as low embryo implantation rate, ...

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Application Information

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IPC IPC(8): G16H70/40
CPCG16H70/40
Inventor 李蓉徐慧玉冯国双韩勇乔杰
Owner GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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