Catalyst for catalyzing synthesis of indoxacarb key intermediate and application of catalyst

Abstract

The invention relates to the field of chemical synthesis, and particularly discloses a catalyst for catalyzing the synthesis of an indoxacarb key intermediate and application of the catalyst. According to the catalyst, metal in metal compounds such as a manganese compound, a copper compound and a zirconium compound is used as a coordination center, cinchona alkaloid chiral compounds such as dihydroquinidine (DHQD) are used as ligands to form a chiral complex catalyst, the novel catalyst is applied to an asymmetric synthesis reaction of tert-butyl hydroperoxide and 5-chloro-2-methoxycarbonyl-1-indanone ester, the selectivity in the asymmetric synthesis process is greatly improved, and the content of an S-form is increased from 75% to 99% or above; and moreover, the use amount of the catalyst is low, a synthesis process is simple, it is conducive to industrialization, and a good foundation is laid for production of high-quality indoxacarb.

Description

technical field [0001] The invention relates to the field of chemical synthesis, and specifically discloses a catalyst for catalyzing the synthesis of key intermediates of indoxacarb and its application. Background technique [0002] Indoxacarb is a new type of oxadiazine insecticide with high efficiency and low toxicity developed by DuPont Company of the United States. It has dual effects of contact killing and stomach poisoning, and can effectively solve resistant pests. It has no cross-resistance with other insecticides such as pyrethroids, organophosphorus, and carbamates, and can well solve the problems of rice leaf rollers, rice stem borers and resistant diamondback moths that are difficult to control in the market. In addition, indoxacarb has a very wide insecticidal spectrum, and one drug can prevent multiple diseases. While preventing and controlling noctuid pests, it also has a good inhibitory effect on mirid bugs, so it is a very good comprehensive management tool...

AI Technical Summary

Problems solved by technology

[0004] First, cinchona base catalysts such as cinchonin are used, but the efficiency of this type of catalyst is low, and the S body content of the synthesized indoxacarb original drug is about 70%;

[0005] Second, metal complex catalysts are used. In 2007, DuPont Company of the United States reported a metal zirconium catalyst, but this type of catalyst is used in a large amount, and the production cost is high, and the S body content of the obtained indoxacarb original drug is about 90%. ;

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