Industrial-grade cis-propenyl phosphoric acid analysis method

A cis-acrylophosphoric acid and analysis method technology, applied in the field of analysis, can solve problems such as high cost and complicated operation process, and achieve the effects of low cost, simple experimental operation, convenience and practicability

Inactive Publication Date: 2019-11-22
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But, the technical operation process used now is complicated, and cost is high, be badly in need of research and d

Method used

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  • Industrial-grade cis-propenyl phosphoric acid analysis method
  • Industrial-grade cis-propenyl phosphoric acid analysis method
  • Industrial-grade cis-propenyl phosphoric acid analysis method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of analytical method of industrial cis-acrylic phosphoric acid of the present embodiment, comprises the following steps:

[0030] Step 1: Prepare the solution

[0031] (1) Preparation of the cis-acrylphosphoric acid solution (2.425g / L) to be tested: Accurately measure 1mL of industrial cis-acrylphosphoric acid, weighing 0.970g, dilute it to a 100mL volumetric flask, and obtain a concentration of 9.7g / L sample solution, and then dilute this solution 4 times to obtain a sample solution with a concentration of 2.425g / L;

[0032] (2) Preparation of 20g / L iodine-ethanol solution: Accurately weigh 5g of iodine elemental substance and dissolve it in absolute ethanol, then transfer it to a 250mL volumetric flask with ethanol;

[0033] (3) Preparation of 20% potassium iodide solution: accurately weigh 50 g of potassium iodide solid reagent, dissolve it in distilled water and set the volume in a 250 mL volumetric flask;

[0034] (4) Preparation of 0.1mol / L sodium thiosu...

Embodiment 2

[0050] A kind of analytical method of industrial cis-acrylic phosphoric acid of the present embodiment, comprises the following steps:

[0051] Step 1: Prepare the solution

[0052] (1) Preparation of the cis-acrylphosphoric acid solution (2.425g / L) to be tested: Accurately measure 1mL of industrial cis-acrylphosphoric acid, weighing 0.970g, dilute it to a 100mL volumetric flask, and obtain a concentration of 9.7g / L sample solution, and then dilute this solution 4 times to obtain a sample solution with a concentration of 2.425g / L;

[0053] (2) Preparation of 10g / L iodine-ethanol solution: Accurately weigh 5g of iodine elemental substance and dissolve it in absolute ethanol, then transfer it to a 500mL volumetric flask with ethanol;

[0054] (3) Preparation of 10% potassium iodide solution: accurately weigh 2.5 g of potassium iodide solid reagent, dissolve it in distilled water and set the volume in a 250 mL volumetric flask;

[0055] (4) Preparation of 0.1mol / L sodium thios...

Embodiment 3

[0071] A kind of analytical method of industrial cis-acrylic phosphoric acid of the present embodiment, comprises the following steps:

[0072] Step 1: Prepare the solution

[0073] (1) Preparation of the cis-acrylphosphoric acid solution (2.425g / L) to be tested: Accurately measure 1mL of industrial cis-acrylphosphoric acid, weighing 0.970g, dilute it to a 100mL volumetric flask, and obtain a concentration of 9.7g / L sample solution, and then dilute this solution 4 times to obtain a sample solution with a concentration of 2.425g / L;

[0074] (2) Preparation of 10g / L iodine-ethanol solution: Accurately weigh 5g of iodine elemental substance and dissolve it in absolute ethanol, then transfer it to a 500mL volumetric flask with ethanol;

[0075] (3) Preparation of 10% potassium iodide solution: accurately weigh 25 g of potassium iodide solid reagent, dissolve it in distilled water and set the volume in a 250 mL volumetric flask;

[0076] (4) Preparation of 0.1mol / L sodium thiosu...

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Abstract

The invention discloses an industrial-grade cis-propenyl phosphoric acid analysis method, which belongs to the technical field of chemical analysis and detection. Specifically, the content of cis-propenyl phosphoric acid is determined by measuring unsaturated double bonds in industrial cis-propenyl phosphoric acid through iodometry. The method is simple and convenient in experimental operation, common and easily available in experimental instruments and reaction reagents, strong in convenience and practicability and low in cost, can be used for similar reaction analysis, and has certain significance for quality monitoring in the research and development pharmaceutical process.

Description

technical field [0001] The invention belongs to the technical field of chemical analysis and detection, and in particular relates to an analysis method of industrial grade cis-acrylophosphate. Background technique [0002] Fosfomycin sodium is a new type of broad-spectrum antibiotic. Its bactericidal mechanism is to inhibit the early synthesis of bacterial cell walls. The chance of anaphylactic shock is very small. It is mainly used to treat infections of the urinary tract, skin, soft tissue and intestinal tract. , has a strong bactericidal effect on most Gram-positive bacteria and Gram-negative bacteria, and is widely used clinically and has a large market demand. Among them, (1R,2S)-(-)-cis-1,2-epoxypropylphosphonic acid (R)-(+)-α-phenethylamine salt, referred to as left phosphorus and right amine salt, is a synthetic fosfomycin It is an important intermediate of element, which is usually prepared by hydrogenation of cis-propylene phosphate, and its impurity content direc...

Claims

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Application Information

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IPC IPC(8): G01N31/16
CPCG01N31/16
Inventor 祝宏李雪方世通刘慧曾祥聪陈家宝李丽李爽
Owner WUHAN INSTITUTE OF TECHNOLOGY
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