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Preparation method of Fe3O4 nano-rod material capable of being used for magnetic hyperthermia agents

A technology of nanorods and thermotherapy agent is applied in the biomedical application field of nanomaterials, which can solve the problems of lack of magnetothermal properties of nanorod materials, and achieve the effects of less uncontrollable factors, increased heating rate, and simple experimental operation.

Active Publication Date: 2019-11-12
THE FIRST HOSPITAL OF LANZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to its tunable aspect ratio and strong anisotropy, nanorod materials have magnetic properties that are easy to match with other shape materials, while Fe 3 o 4 There is no corresponding literature report on the magnetocaloric properties of nanorod materials

Method used

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  • Preparation method of Fe3O4 nano-rod material capable of being used for magnetic hyperthermia agents
  • Preparation method of Fe3O4 nano-rod material capable of being used for magnetic hyperthermia agents
  • Preparation method of Fe3O4 nano-rod material capable of being used for magnetic hyperthermia agents

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Effect test

Embodiment 1

[0027] Weigh 1.6g FeCl 3 ·6H2 O and it was dissolved in 60mL deionized water, and the prepared solution was transferred to a high-pressure hydrothermal reactor with a volume of 100mL and sealed. Then, the reactor was placed in an oven at 100° C. for hydrothermal reaction for 4 h, and then cooled to room temperature naturally. Subsequently, the yellow precipitate obtained in the experiment was washed three times with deionized water and alcohol, centrifuged and dried at 60°C to obtain a yellow powder β-FeOOH, which we named FeOOH-4h here. Subsequently, 20 mg of β-FeOOH powder was weighed, put into 6 mL of trioctylamine, and sonicated in an ultrasonic cleaner for 2 hours to uniformly disperse them in trioctylamine. Add 200 μL of oleic acid to the suspension obtained after dispersion, stir thoroughly for 1 h, then transfer the obtained mixture to a centrifuge, and centrifuge at 7500 rpm for 5 min to obtain a gel-like mixture. Transfer the above mixture to a sealed high-temperat...

Embodiment 2

[0030] Weigh 1.6g FeCl 3 ·6H 2 O and it was dissolved in 60mL deionized water, and the prepared solution was transferred to a high-pressure hydrothermal reactor with a volume of 100mL and sealed. Then the reactor was placed in an oven at 100 °C for 10 h, and then cooled to room temperature naturally. Subsequently, the yellow precipitate obtained in the experiment was washed three times with deionized water and alcohol, centrifuged and dried at 80°C to obtain a yellow powder β-FeOOH, which we named FeOOH-10h here. Subsequently, 20 mg of β-FeOOH powder was weighed, put into 6 mL of trioctylamine, and sonicated in an ultrasonic cleaner for 2 hours to uniformly disperse them in trioctylamine. Add 200 μL of oleic acid to the suspension obtained after dispersion, stir thoroughly for 2 hours, then transfer the obtained mixture to a centrifuge, and centrifuge at 7500 rpm for 15 minutes to obtain a gel-like mixture. Transfer the above mixture to a sealed high-temperature tube furnac...

Embodiment 3

[0033] Weigh 1.6g FeCl 3 ·6H 2 O and it was dissolved in 60mL deionized water, and the prepared solution was transferred to a high-pressure hydrothermal reactor with a volume of 100mL and sealed. Then the reactor was placed in an oven at 100 °C for 6 h, and then cooled to room temperature naturally. Subsequently, the yellow precipitate obtained in the experiment was washed five times with deionized water and alcohol respectively, centrifuged and dried at 60°C to obtain a yellow powder β-FeOOH, which we named FeOOH-6h here. Subsequently, 20 mg of β-FeOOH powder was weighed, put into 6 mL of trioctylamine, and ultrasonicated for 3 h in an ultrasonic cleaner to uniformly disperse them in trioctylamine. Add 200 μL of oleic acid to the suspension obtained after dispersion, stir thoroughly for 1 h, then transfer the obtained mixture to a centrifuge, and centrifuge at 8500 rpm for 5 min to obtain a gel-like mixture. Transfer the above mixture to a sealed high-temperature tube furn...

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Abstract

The invention discloses a preparation method of a Fe3O4 nano-rod material capable of being used for magnetic hyperthermia agents. The method comprises: synthesizing a Fe3O4 magnetic material with a nano-rod shape by using FeCl3.6H2O as a raw material through a hydrothermal reaction and a high temperature annealing method. According to the present invention, the method has characteristics of simpleexperiment operation and few uncontrollable factors, and can perform large-scale preparation in a universal environment; and the Fe3O4 nano-rod material prepared by the method has good magnetocaloricproperty, and can meet the research and development of magnetic hyperthermia agents for tumor in medicine so as to increase the magnetic hyperthermia effect.

Description

technical field [0001] The invention belongs to the field of biomedical application of nanomaterials, in particular to a Fe 3 o 4 Preparation method of nanorod material. Background technique [0002] In recent years, as the preparation technology of magnetic nanomaterials continues to mature and the types are gradually enriched, the research field of this material is also expanding accordingly. In addition to the research and development of traditional electronic devices to the application of magnetic storage devices, magnetic nanomaterials are currently used in bioscience technology, biomedicine, etc. due to their good biological safety, surface modification, special in vivo performance and unique magnetic properties It is involved in many research fields and shows considerable application prospects. These include the treatment of malignant tumors as a high-performance magnetothermic agent. That is to use biomedical magnetic nanomaterials to load drugs, which are direct...

Claims

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Application Information

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IPC IPC(8): C01G49/08B82Y30/00B82Y40/00
CPCC01G49/08B82Y30/00B82Y40/00C01P2004/16C01P2004/62C01P2004/64C01P2006/42C01P2006/32
Inventor 梁晓磊杨永秀高大强
Owner THE FIRST HOSPITAL OF LANZHOU UNIV
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