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Pharmaceutical composition for treating pulmonary nodules and preparation method thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its preparation for the treatment of pulmonary nodules, which can solve problems such as limited selection of treatment options, waste of medical resources, and difficulties in the early diagnosis of pulmonary nodules

Inactive Publication Date: 2019-11-12
北京东方运嘉科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once pulmonary nodules are found, pathological and cytological examinations are the gold standard for determining benign and malignant pulmonary nodules. However, as an invasive examination method, it is very difficult to be practically applied in the process of clinical diagnosis and treatment
Due to the difficulty in early diagnosis of pulmonary nodules, treatment options are more limited
Thoracic surgery is often accompanied by high risks, but in addition to active surgical resection, patients can only receive empirical anti-inflammatory or anti-tuberculosis treatment and regular follow-up visits, which brings different degrees of mental pressure to patients with pulmonary nodules , some patients undergo frequent CT examinations, resulting in a huge waste of medical resources and bringing more economic burdens to the society
At present, Western medicine generally believes that benign nodules will exist for a long time, and there is no drug that can eliminate small nodules

Method used

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  • Pharmaceutical composition for treating pulmonary nodules and preparation method thereof
  • Pharmaceutical composition for treating pulmonary nodules and preparation method thereof
  • Pharmaceutical composition for treating pulmonary nodules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Pseudostellaria 15g, golden buckwheat 15g, Scutellaria barbata 15g, Hedyotis diffusa 15g, Fritillaria 10g, Prunella vulgaris 10g, Cyperus cyperi 10g. Take the above-mentioned Chinese herbal medicine, add water twice the volume of the medicinal material, decoct twice, combine the two filtrates, and concentrate the medicinal liquid to contain 1 g of crude drug per milliliter.

Embodiment 2

[0072] Weigh the raw materials according to the following weight ratios for later use: 1500g of heterophylla, 1500g of golden buckwheat, 1500g of Scutellaria barbata, 1500g of Hedyotis diffusa, 1000g of Fritillaria japonicus, 1000g of Prunella vulgaris, and 1000g of Rhizoma Cyperus. Add 8 times the amount of hot water, soak for 1.5 hours, heat and decoct, decoct for 1.5 hours, filter; add 6 times the amount of water to the dregs, heat and decoct for 1 hour, filter; combine the filtrates, separate the solids; Concentrate to a relative density of 1.08, enter the spray dryer, control the inlet air temperature at 140°C, the outlet air temperature at 110°C, the atomizer rotation speed at 45 rpm, and the feed rate at 5ml / min to obtain spray-dried powder, crush and sieve Then get fine powder. Add conventional pharmaceutically acceptable excipients to make tablets.

Embodiment 3

[0074] Weigh each raw material according to the following weight proportions for later use: 600g of heterophylla, 600g of golden buckwheat, 600g of Scutellaria barbata, 600g of Hedyotis diffusa, 400g of Fritillaria japonicus, 400g of Prunella vulgaris, and 400g of Rhizoma Cyperus. Add 10 times the amount of water, decoct for 2 hours, filter; add 8 times the amount of water to the dregs, decoct for 1 hour, filter; combine the filtrates, slowly add absolute ethanol, stir while adding, so that the alcohol content reaches The amount of alcohol is gradually increased to 75%, and filtered; the above-mentioned medicinal solution is concentrated to a relative density of 1.08, and then enters the spray dryer, the inlet air temperature is controlled at 140°C, the outlet air temperature is 110°C, the atomizer speed is 45 rpm, and the feed The speed is 5ml / min, and the spray-dried powder is obtained, and conventional pharmaceutically acceptable adjuvants are added to make capsules.

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Abstract

The invention relates to a pharmaceutical composition for treating pulmonary nodules and a preparation method thereof. The composition is composed of pseudostellaria root, wild buckwheat rhizome, barbat skullcap, Hedyotis diffusa, bulbus fritillariae thunbergii, prunella vulgaris and Cyperus Rotundus L. The composition is based on the disease which is characterized in that qi deficiency is the fundamental internal cause, and phlegm heat and toxic condensate are pathological products, the method of benefiting qi and detoxifying and dissolving nodules is proposed through dialectical treatment, and the effect of stabilizing and reducing nodules and preventing canceration is adjusted by adjusting the constitution of patients. The invention also provides the method for preparing the compositionand its pharmaceutical use.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, more specifically, a pharmaceutical composition for treating pulmonary nodules and a preparation method thereof. Background technique [0002] According to the statistics released by the National Cancer Center, in 2015 China is expected to have 4,292,000 new cancer cases and 2,814,000 deaths, among which lung cancer is the cancer with the highest incidence rate and the number one cancer death. With the improvement of computed tomography (CT) technology and the popularity of screening high-risk groups of lung cancer, more and more small pulmonary nodules have been found, and the detection rate of pulmonary nodules (PN) increase. [0003] Pulmonary nodules are a granulomatous disease that occurs in the lungs, clinically including benign and malignant nodules. Among small pulmonary nodules, very few may be early lung cancer, especially ground-glass nodules, which need to be paid attenti...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61P11/00A61P35/00
CPCA61K36/36A61K36/536A61K36/539A61K36/70A61K36/748A61K36/8905A61K36/8966A61K2236/331A61K2236/51A61K2236/53A61P11/00A61P35/00A61K2300/00
Inventor 晁恩祥晁燕曾风英王小花王宏图
Owner 北京东方运嘉科技发展有限公司
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