Application of decenotinib in preparation of externally applied medicine for treating psoriasis, medicine and preparation method of medicine

A technology for external use of drugs and psoriasis, which can be used in drug combination, drug delivery, pharmaceutical formulations, etc., to solve problems such as unclear development mechanism of psoriasis

Pending Publication Date: 2019-11-05
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanism of occurrence and development of psoriasis is still unclear, and the currently approved drugs are limited

Method used

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  • Application of decenotinib in preparation of externally applied medicine for treating psoriasis, medicine and preparation method of medicine
  • Application of decenotinib in preparation of externally applied medicine for treating psoriasis, medicine and preparation method of medicine
  • Application of decenotinib in preparation of externally applied medicine for treating psoriasis, medicine and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0060] The present invention provides a preparation method of any one of the above-mentioned external medicines for treating psoriasis, which includes the following steps: mixing Decernotinib with a matrix, and then suffice.

[0061] Further, the preparation method of the external medicine of above-mentioned ointment comprises the following steps:

[0062] Decernotinib was dissolved in DMSO to prepare a Decernotinib solution. The lanolin and white petrolatum are heated and dissolved, added to the Decernotinib solution, and stirred evenly to prepare the above-mentioned external ointment for treating psoriasis. The ointment for external use is in the form of ointment and can be directly applied to the skin surface of the patient.

[0063] Specifically, the condition for heating and dissolving lanolin and white petrolatum is heating at 60-70° C. for 15-30 minutes. Preferably, the condition for heating and dissolving lanolin and white petrolatum is heating at 65° C. for 20 minut...

Embodiment 1

[0071] The injection medicament for treating psoriasis of embodiment 1 is mixed with DMSO to make injection medicament by Decernotinib. Wherein the mass ratio of Decernotinib to injection drug is 16mg:1Kg.

[0072] Embodiment 1~5 is the ointment medicine for the treatment of psoriasis

[0073] Example 1

[0074] The ointment medicine for treating psoriasis of Example 1 is prepared by parts by weight from 0.025 parts of Decernotinib, 9 parts of lanolin, 90 parts of white petrolatum, and 0.4 parts of DMSO.

[0075] The preparation method comprises the following steps: dissolving Decernotinib in DMSO to prepare a Decernotinib solution. The lanolin and white petrolatum were heated at 65° C. for 20 minutes to dissolve, the Decernotinib solution was added, and the mixture was evenly stirred to prepare the ointment medicine for treating psoriasis.

Embodiment 2

[0076] The ointment medicine for treating psoriasis of Example 2 is basically the same as that of Example 1, except that the parts by weight of Decernotinib are 0.15 parts. The steps of the preparation method are all similar.

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Abstract

The invention relates to an application of decenotinib in preparation of an externally applied medicine for treating psoriasis, a medicine and a preparation method of the medicine. A researcher findsthat the externally applied medicine prepared from decernotinib, which is originally used for treating rheumatoid arthritis and is an oral medicine, has an effect of treating psoriasis through a research. The application provides a new use for decenotinib and provides a new medicine for treatment of psoriasis. The research finds that decernotinib applied to the externally applied medicine has obvious medicinal efficacy in treatment of psoriasis and the application prospect is wide, so the decernotinib has great promotion and application value. Because decernotinib is a conventional drug, the toxicology and pharmacology are relatively clear, and thus the cost of research and development is reduced.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to an application, medicine and preparation method of Decernotinib in the preparation of external medicine for treating psoriasis. Background technique [0002] Psoriasis is a common chronic inflammatory disease in dermatology. The main clinical manifestation is scaly erythema on the trunk and extremities, which can spread to the whole body and easily recurs. Psoriasis vulgaris is the most common type of psoriasis. At present, there are many drugs for the treatment of psoriasis vulgaris, most of which are hormones and immunosuppressant drugs, such as glucocorticoids, retinoic acid drugs and vitamin D3 analogues. The pathogenesis of psoriasis is complicated. Although there are many clinical treatment methods, the curative effect is not satisfactory, which seriously affects the quality of life of patients. [0003] With recent research on psoriasis, psoriasis is a common immune-med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/506A61K9/06A61K47/06A61K47/44A61P17/06
CPCA61K31/506A61K9/0014A61K9/06A61K47/06A61K47/44A61P17/06
Inventor 彭聪陈翔颜蓓
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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