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Migraine biomarker and use thereof

A biomarker and migraine technology, applied in the field of biomedicine, can solve the problems that migraine diagnostic methods cannot achieve early warning, and cannot predict the onset and development trend of migraine, so as to achieve comfortable and non-invasive testing and ensure accuracy Effect

Active Publication Date: 2019-11-01
SHENZHEN HUADA GENE INST
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, the purpose of the present invention is to provide biomarkers for assessing the risk of migraine or early diagnosis of migraine, as well as a method for diagnosing and assessing the risk of migraine, which can solve the problem that the existing migraine diagnosis methods cannot achieve early warning, inability to Disadvantages such as predicting the onset and development trend of migraine

Method used

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  • Migraine biomarker and use thereof
  • Migraine biomarker and use thereof
  • Migraine biomarker and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0094] 1.1 Sample collection

[0095] Referring to the method described in A metagenome-wide association study of gut microbiota in type2 diabetes (Qin, J. et al. Nature 490, 55-60 (2012)), the feces samples were collected and transported frozen and quickly transferred to -80°C for storage , carry out DNA extraction, and obtain the extracted DNA sample. Stool samples from migraine and non-migraine subjects were obtained from adult twins in the UK, totaling 250 individuals, and then 29 samples with missing phenotypes were discarded from the 250 total samples, according to The remaining 221 samples include 167 healthy samples and 54 migraine samples.

[0096] 1.2 Metagenome sequencing and assembly

[0097]The extracted DNA samples were used to construct a sequencing library, and two-way (Paired-end) metagenomic sequencing (insert fragment 350bp, read length 100bp) was performed on the Illumina HiSeq2000 sequencing platform. Filter the data generated by sequencing (quality-con...

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Abstract

The present invention relates to the field of biomedicines and particularly relates to a migraine biomarker and an application thereof. The provided migraine biomarker comprises at least one selectedfrom the following: bacteroides thetaiotaomicron and / or analogues thereof, faecalibacterium prausnitzii and / or analogues thereof, bacteroides intestinalis and / or analogues thereof and anaeroridus colihominis and / or analogues thereof. The present invention provides the biomarker for early diagnosis of the migraine, and a diagnosis and disease risk assessment method of the migraine, and can solve problems that the existing migraine diagnosis method cannot conduct early warn, cannot predict migraine attack, etc.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to migraine biomarkers and uses thereof. Specifically, the present invention relates to a biomarker for migraine or related diseases, a method for diagnosing or predicting the risk of migraine or related diseases, a kit, and the use of migraine biomarkers in the preparation of the kit. Background technique [0002] Migraine (English: Migraine) is a chronic disease with recurrent mild or severe headaches, usually accompanied by various autonomic nervous system symptoms. Migraine is usually localized, recurrent, and self-limited severe headache with associated symptoms of the autonomic nervous system. 15-30% of people with a history of migraine have symptoms of aura, and those who have aura of migraine often have symptoms without aura. The severity of pain, duration and frequency of headaches vary from person to person. A migraine that lasts longer than 72 hours is called status migraine...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12Q1/689
CPCC12Q1/6883C12Q1/689C12Q2600/136
Inventor 郭锐进王奇贾慧珏鞠艳梅
Owner SHENZHEN HUADA GENE INST
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