Migraine biomarker and use thereof
A biomarker and migraine technology, applied in the field of biomedicine, can solve the problems that migraine diagnostic methods cannot achieve early warning, and cannot predict the onset and development trend of migraine, so as to achieve comfortable and non-invasive testing and ensure accuracy Effect
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[0094] 1.1 Sample collection
[0095] Referring to the method described in A metagenome-wide association study of gut microbiota in type2 diabetes (Qin, J. et al. Nature 490, 55-60 (2012)), the feces samples were collected and transported frozen and quickly transferred to -80°C for storage , carry out DNA extraction, and obtain the extracted DNA sample. Stool samples from migraine and non-migraine subjects were obtained from adult twins in the UK, totaling 250 individuals, and then 29 samples with missing phenotypes were discarded from the 250 total samples, according to The remaining 221 samples include 167 healthy samples and 54 migraine samples.
[0096] 1.2 Metagenome sequencing and assembly
[0097]The extracted DNA samples were used to construct a sequencing library, and two-way (Paired-end) metagenomic sequencing (insert fragment 350bp, read length 100bp) was performed on the Illumina HiSeq2000 sequencing platform. Filter the data generated by sequencing (quality-con...
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